对尿路感染的免疫反应的本质。
The nature of immune responses to urinary tract infections.
作者信息
Abraham Soman N, Miao Yuxuan
机构信息
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Nat Rev Immunol. 2015 Oct;15(10):655-63. doi: 10.1038/nri3887. Epub 2015 Sep 21.
Abstract
The urinary tract is constantly exposed to microorganisms that inhabit the gastrointestinal tract, but generally the urinary tract resists infection by gut microorganisms. This resistance to infection is mainly ascribed to the versatility of the innate immune defences in the urinary tract, as the adaptive immune responses are limited particularly when only the lower urinary tract is infected. In recent years, as the strengths and weaknesses of the immune system of the urinary tract have emerged and as the virulence attributes of uropathogens are recognized, several potentially effective and unconventional strategies to contain or prevent urinary tract infections have emerged.
摘要
尿路持续暴露于寄居于胃肠道的微生物中，但一般来说，尿路能够抵抗肠道微生物的感染。这种抗感染能力主要归因于尿路固有免疫防御的多样性，因为适应性免疫反应有限，尤其是在下尿路仅被感染时。近年来，随着尿路免疫系统的优缺点逐渐显现，以及尿路病原体毒力特性被认识，出现了几种控制或预防尿路感染的潜在有效且非常规的策略。
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