注意——并非所有尿路感染都是相同的。
CAUTIon - not all UTIs are the same.
作者信息
Molina Jonathan J, Flores-Mireles Ana L
机构信息
Integrated Biomedical Sciences, University of Notre Dame, Notre Dame, IN, USA.
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
出版信息
Nat Rev Urol. 2025 Aug 1. doi: 10.1038/s41585-025-01065-z.
Urinary tract infections are one of the most common infections, accounting for ~400 million diagnoses per year worldwide. Uncomplicated urinary tract infections (uUTIs) occur in healthy individuals with no structural or functional abnormalities of the urinary system and primarily affect women. Catheter-associated urinary tract infections (CAUTIs) are a type of complicated UTI affecting patients who have a urinary catheter in place, often hospitalized patients or patients with conditions that prevent them from urinating naturally. Both infections share common symptoms, diagnostics and treatment options but also differ greatly in pathophysiology, aetiology, risk factors and comorbidities. These differences could explain why antibiotic treatments - which generally lead to positive outcomes in patients with uUTIs - often fail in patients with CAUTIs. Understanding these differences could guide evidence-based insights into why treatments for CAUTIs should be different from those for uUTIs, specifically, by modifying catheters, which initiate the damage-induced segue for UTIs.
尿路感染是最常见的感染之一，全球每年约有4亿例诊断病例。单纯性尿路感染（uUTIs）发生在泌尿系统无结构或功能异常的健康个体中，主要影响女性。导管相关性尿路感染（CAUTIs）是一种复杂性尿路感染，影响有导尿管的患者，通常是住院患者或因病情无法自然排尿的患者。这两种感染有共同的症状、诊断方法和治疗选择，但在病理生理学、病因、危险因素和合并症方面也有很大差异。这些差异可以解释为什么抗生素治疗——通常能使uUTIs患者取得积极疗效——在CAUTIs患者中常常失败。了解这些差异可以为基于证据的见解提供指导，即为什么CAUTIs的治疗应与uUTIs的治疗不同，特别是通过改进导尿管，导尿管引发了导致尿路感染的损伤性转变。
Zotero 插件