Suh Sung-Eun, Barros Stephanie A, Chenoweth David M
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104 (USA).
Chem Sci. 2015;6(9):5128-5132. doi: 10.1039/C5SC01726B.
One of the most challenging goals of modern synthetic chemistry is to develop multi-step reactions for rapid and efficient access to complex molecules. We report a triple aryne-tetrazine reaction that enables rapid access to a new class of polyaromatic heterocycles. This new reaction, which couples diverse reactivity modes between simple aryne and tetrazine starting materials, proceeds in a single operation and takes less than 5 minutes in air with no metal catalyst.
现代合成化学最具挑战性的目标之一是开发多步反应，以便快速高效地合成复杂分子。我们报道了一种三芳炔-四嗪反应，该反应能够快速合成一类新型的多环芳烃杂环化合物。这种新反应将简单芳炔和四嗪起始原料之间的多种反应模式结合在一起，只需一步操作，在空气中不到5分钟即可完成，无需金属催化剂。
