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早期和晚期精神分裂症患者认知功能及日常生活技能的差异

Differences in cognitive function and daily living skills between early- and late-stage schizophrenia.

作者信息

Kim Sung-Jin, Shim Joo-Cheol, Kong Bo-Geum, Kang Je-Wook, Moon Jung-Joon, Jeon Dong-Wook, Seo Young-Soo, Oh Min-Kyung, Jung Do-Un

机构信息

a Department of Psychiatry , Busan Paik Hospital, Inje University , Busan , Korea.

b Shim Joo Cheol Psychiatry Clinic , Busan , Korea.

出版信息

Int J Psychiatry Clin Pract. 2015;19(4):245-51. doi: 10.3109/13651501.2015.1084328. Epub 2015 Sep 21.

Abstract

OBJECTIVES

Cognitive dysfunction is a core feature of schizophrenia; deficits often manifest prior to diagnosis and persist throughout the course of the illness. This study was performed to assess the difference in cognitive function and daily living skills between the early- and late-stage schizophrenia.

METHODS

Fifty-five clinically stable patients with schizophrenia were recruited (25 with < 5-year and 30 with > 5-year disease durations). We evaluated subjects' clinical states, cognitive function, and psychosocial factors. The Korean versions of MATRICS Consensus Cognitive Battery and UCSD Performance-based Skills Assessment were used for evaluating cognitive function and daily living skills. Chi-square, Wilcoxon rank sum, and t-tests were used to analyze the data.

RESULTS

The two groups did not differ for most demographic variables. No significant differences between groups were found for clinical symptoms, psychosocial factors, or non-social cognitive domains. However, the early-stage group had higher social cognition domain scores than the late-stage group (p = 0.01). Early-stage patients scored significantly higher than those in the late-stage group did in the communication and comprehension/planning domains (p = 0.037 and 0.027, respectively), and total score (p = 0.003) of the Performance-based Skills Assessment.

CONCLUSIONS

We observed significant differences between patients with early- and late-stage illness with regard to social cognition and performance-based skills.

摘要

目的

认知功能障碍是精神分裂症的核心特征;缺陷通常在诊断之前就已出现,并在疾病过程中持续存在。本研究旨在评估早期和晚期精神分裂症患者在认知功能和日常生活技能方面的差异。

方法

招募了55名临床症状稳定的精神分裂症患者(25名病程<5年,30名病程>5年)。我们评估了受试者的临床状态、认知功能和社会心理因素。采用韩国版的MATRICS共识认知成套测验和基于UCSD表现的技能评估来评估认知功能和日常生活技能。使用卡方检验、Wilcoxon秩和检验和t检验来分析数据。

结果

两组在大多数人口统计学变量上没有差异。在临床症状、社会心理因素或非社会认知领域方面,两组之间未发现显著差异。然而,早期组的社会认知领域得分高于晚期组(p = 0.01)。早期患者在基于表现的技能评估的沟通和理解/计划领域(分别为p = 0.037和0.027)以及总分(p = 0.003)方面的得分显著高于晚期组患者。

结论

我们观察到早期和晚期疾病患者在社会认知和基于表现的技能方面存在显著差异。

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