Szabo Shelagh, Merikle Elizabeth, Lozano-Ortega Greta, Powell Lauren, Macek Thomas, Cline Stephanie
Broadstreet HEOR, Vancouver, BC, Canada.
Takeda Pharmaceuticals, Deerfield, IL, USA.
Schizophr Res Treatment. 2018 Dec 27;2018:9075174. doi: 10.1155/2018/9075174. eCollection 2018.
To perform a systematic review of the published literature to evaluate how functional capacity, as measured by the University of California at San Diego (UCSD) Performance-based Skills Assessment (UPSA), relates to other functional measures and real-world outcomes among individuals with schizophrenia.
The MEDLINE® and Embase® databases were searched to identify joint evaluations with UPSA and key functional outcomes (functional scale measures; generic or disease-specific, health-related quality of life [HRQoL]; or real-world outcomes [residential status; employment status]) in patients with schizophrenia. Pearson correlations were estimated between UPSA scores, HRQoL, other functional scale measures, and real-world outcomes, for outcomes described in at least six studies.
The synthesis included 76 studies that provided 73 unique data sets. Quantitative assessment between the Specific Level of Function (SLOF) (n=18) scores and UPSA scores demonstrated a moderate borderline-significant correlation (0.45, =0.06). Quantitative analysis of the relationship between the Global Assessment of Functioning (GAF) (n=11) and the Multidimensional Scale of Independent Functioning (MSIF) (n=6) scales revealed moderate and small nonsignificant Pearson correlations of -0.34 (0.31) and 0.12 (0.83), respectively. There was a small borderline-significant correlation between UPSA score and residential status (n=36; 0.31; 0.08), while no correlation was found between UPSA score and employment status (n=19; 0.04; =0.88).
The SLOF was the most often used functional measure and had the strongest observed correlation with the UPSA. Although knowledge gaps remain, evidence from this review indicates that there is a quantitative relationship between functional capacity and real-world outcomes in individuals with schizophrenia.
对已发表的文献进行系统综述，以评估加利福尼亚大学圣地亚哥分校（UCSD）基于表现的技能评估（UPSA）所衡量的功能能力如何与精神分裂症患者的其他功能指标及实际生活结果相关。
检索MEDLINE®和Embase®数据库，以识别精神分裂症患者中UPSA与关键功能结果（功能量表测量；通用或疾病特异性的、与健康相关的生活质量[HRQoL]；或实际生活结果[居住状况；就业状况]）的联合评估。对于至少六项研究中描述的结果，估计UPSA评分、HRQoL、其他功能量表测量和实际生活结果之间的Pearson相关性。
该综述纳入了76项研究，提供了73个独特的数据集。特定功能水平（SLOF）（n = 18）评分与UPSA评分之间的定量评估显示出中度临界显著相关性（0.45，P = 0.06）。对功能总体评估（GAF）（n = 11）和独立功能多维量表（MSIF）（n = 6）量表之间关系的定量分析显示，Pearson相关性分别为中度和小度且无显著性，分别为-0.34（P = 0.31）和0.12（P = 0.83）。UPSA评分与居住状况之间存在小度临界显著相关性（n = 36；0.31；P = 0.08），而UPSA评分与就业状况之间未发现相关性（n = 19；0.04；P = 0.88）。
SLOF是最常用的功能测量方法，并且与UPSA的观察相关性最强。尽管仍存在知识空白，但本综述的证据表明，精神分裂症患者的功能能力与实际生活结果之间存在定量关系。
