Cortés-Castell Ernesto, Sánchez-González Pablo, Palazón-Bru Antonio, Bosch-Giménez Vicente, Manero-Soler Herminia, Juste-Ruiz Mercedes, Rizo-Baeza María Mercedes, Gil-Guillén Vicente Francisco
Department of Pharmacology, Paediatrics and Organic Chemistry, Miguel Hernández University, San Juan de Alicante, Spain.
Clinical Analysis Department, Alicante General University Hospital, Alicante, Spain.
PLoS One. 2015 Sep 21;10(9):e0138532. doi: 10.1371/journal.pone.0138532. eCollection 2015.
To analyse the association in newborns between blood levels of phenylalanine and feeding method and gestational age.
This observational, cross-sectional study included a sample of 11,829 infants between 2008 and 2013 in a Spanish region. Data were recorded on phenylalanine values, feeding method [breast, formula, mixed (breast plus formula), or partial or fully intravenous feeding], gestational age in weeks (<32, 32-37, ≥37), gender and days since birth at the moment of blood collection. Outcomes were [phenylalanine] and [phenylalanine] ≥95th percentile. Associations were analysed using multivariate models [linear (means difference) and logistic regression (adjusted odds ratios)].
Higher phenylalanine values were associated with lower gestational age (p<0.001) and with intravenous feeding (p<0.001).
The degree of prematurity and intravenous feeding influenced the plasma concentration of phenylalanine in the newborn. Caution should be taken in [phenylalanine] for newborns with intravenous feeding, monitoring them carefully. Very preterm infants given the recommended amount of amino acids should also be strictly monitored. These findings should be taken into consideration and call for adapting the amounts to the needs of the infant.
分析新生儿血液中苯丙氨酸水平与喂养方式及胎龄之间的关联。
这项观察性横断面研究纳入了2008年至2013年西班牙某地区11829名婴儿的样本。记录了苯丙氨酸值、喂养方式[母乳喂养、配方奶喂养、混合喂养（母乳加配方奶）或部分或完全静脉喂养]、以周为单位的胎龄（<32周、32 - 37周、≥37周）、性别以及采血时的出生天数。观察指标为[苯丙氨酸]以及[苯丙氨酸]≥第95百分位数。使用多变量模型[线性模型（均值差异）和逻辑回归（调整后的比值比）]分析关联。
苯丙氨酸值较高与较低的胎龄（p<0.001）以及静脉喂养（p<0.
