Carver J D, Stromquist C I, Benford V J, Minervini G, Benford S A, Barness L A
Department of Pediatrics, University of South Florida College of Medicine, Tampa 33606, USA.
J Perinatol. 1997 Sep-Oct;17(5):389-92.
To measure plasma inositol levels in preterm infants fed formula containing inositol at levels close to those in human milk.
Plasma inositol levels were measured in 72 preterm infants fed formula containing 1110 mumol/L inositol and in cord blood of 12 healthy term infants. Preterm infant plasma levels were measured four times: (1) within the first 7 days of life, (2) intermediate enteral feeding, (3) at hospital discharge, and (4) 2 months after hospital discharge.
Inositol concentrations in term cord blood samples were significantly lower than in preterm initial feeding, intermediate feeding, and discharge samples. Initial concentrations in blood of preterm infants were higher than in all other groups, and were significantly lower among infants with gestational ages of 31 to 33 weeks compared with those of 28 to 30 or 31 to 33 weeks. Days of parenteral nutrition were a significant predictor of inositol levels in the full feeding sample, with lower levels associated with prolonged parenteral nutrition. Clinical outcomes were not related to plasma inositol levels.
Feeding preterm formula with inositol levels close to those reported for human milk may not prevent the postnatal decline in preterm infant plasma inositol levels.
测量喂养含肌醇水平接近母乳的配方奶的早产儿的血浆肌醇水平。
测量了72名喂养含1110微摩尔/升肌醇配方奶的早产儿以及12名健康足月儿脐带血中的血浆肌醇水平。对早产儿的血浆水平进行了4次测量：（1）出生后7天内，（2）肠道喂养中期，（3）出院时，以及（4）出院后2个月。
足月儿脐带血样本中的肌醇浓度显著低于早产儿初次喂养、中期喂养和出院时的样本。早产儿血液中的初始浓度高于所有其他组，与孕28至30周或31至33周的婴儿相比，孕31至33周的婴儿中的浓度显著较低。全量喂养样本中，肠外营养天数是肌醇水平的显著预测因素，肠外营养时间延长与较低水平相关。临床结局与血浆肌醇水平无关。
喂养含肌醇水平接近母乳报道水平的早产配方奶可能无法预防早产儿出生后血浆肌醇水平的下降。
