Zafar Shamsa, Jean-Baptiste Rachel, Rahman Atif, Neilson James P, van den Broek Nynke R
Health Services Academy, Islamabad, Pakistan.
Oxford Epidemiology Services, Oxford, United Kingdom.
PLoS One. 2015 Sep 21;10(9):e0138026. doi: 10.1371/journal.pone.0138026. eCollection 2015.
For more accurate estimation of the global burden of pregnancy associated disease, clarity is needed on definition and assessment of non-severe maternal morbidity. Our study aimed to define maternal morbidity with clear criteria for identification at primary care level and estimate the distribution of and evaluate associations between physical (infective and non-infective) and psychological morbidities in two different low-income countries.
Cross sectional study with assessment of morbidity in early pregnancy (34%), late pregnancy (35%) and the postnatal period (31%) among 3459 women from two rural communities in Pakistan (1727) and Malawi (1732). Trained health care providers at primary care level used semi-structured questionnaires documenting signs and symptoms, clinical examination and laboratory tests which were bundled to reflect infectious, non-infectious and psychological morbidity.
One in 10 women in Malawi and 1 in 5 in Pakistan reported a previous pregnancy complication with 1 in 10 overall reporting a previous neonatal death or stillbirth. In the index pregnancy, 50.1% of women in Malawi and 53% in Pakistan were assessed to have at least one morbidity (infective or non-infective). Both infective (Pakistan) and non-infective morbidity (Pakistan and Malawi) was lower in the postnatal period than during pregnancy. Multiple morbidities were uncommon (<10%). There were marked differences in psychological morbidity: 26.9% of women in Pakistan 2.6% in Malawi had an Edinburgh Postnatal Depression Score (EPDS) > 9. Complications during a previous pregnancy, infective morbidity (p <0.001), intra or postpartum haemorrhage (p <0.02) were associated with psychological morbidity in both settings.
Our findings highlight the need to strengthen the availability and quality of antenatal and postnatal care packages. We propose to adapt and improve the framework and criteria used in this study, ensuring a basic set of diagnostic tests is available, to ensure more robust assessment of non-severe maternal morbidity.
为了更准确地估计妊娠相关疾病的全球负担,需要明确非严重孕产妇发病的定义和评估方法。我们的研究旨在明确基层医疗保健机构识别孕产妇发病的清晰标准,并估计两个不同低收入国家中身体(感染性和非感染性)和心理发病情况的分布,并评估它们之间的关联。
对来自巴基斯坦(1727名)和马拉维(1732名)两个农村社区的3459名妇女进行横断面研究,评估她们在孕早期(34%)、孕晚期(35%)和产后(31%)的发病情况。基层医疗保健机构经过培训的医护人员使用半结构化问卷记录体征和症状、临床检查及实验室检查结果,这些检查综合起来反映感染性、非感染性和心理发病情况。
马拉维每10名妇女中有1名、巴基斯坦每5名妇女中有1名报告曾有过妊娠并发症,总体上每10名妇女中有1名报告曾有过新生儿死亡或死产。在本次妊娠中,马拉维50.1%的妇女和巴基斯坦53%的妇女被评估至少有一种发病情况(感染性或非感染性)。产后感染性发病情况(巴基斯坦)和非感染性发病情况(巴基斯坦和马拉维)均低于孕期。多种发病情况并不常见(<10%)。心理发病情况存在显著差异:巴基斯坦26.9%的妇女、马拉维2.6%的妇女爱丁堡产后抑郁量表(EPDS)得分>9。既往妊娠并发症、感染性发病情况(p<0.001)、产时或产后出血(p<0.02)在两种情况下均与心理发病情况相关。
我们的研究结果凸显了加强产前和产后护理套餐的可及性和质量的必要性。我们建议调整和完善本研究中使用的框架和标准,确保有一套基本的诊断检查,以更有力地评估非严重孕产妇发病情况。