Lin Chen-Yu, Xu Han-Mei
Department of The Engineering Research Center of Peptide Drug Discovery and Development and Department of State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China.
Department of The Engineering Research Center of Peptide Drug Discovery and Development and Department of State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China
Carcinogenesis. 2015 Nov;36(11):1255-62. doi: 10.1093/carcin/bgv136. Epub 2015 Sep 21.
Esophageal carcinoma (EC) is one of the most aggressive cancer types worldwide. However, the underlying genomic events of EC are not fully understood. It is becoming evident that long non-coding RNAs (lncRNAs) play vital roles in tumorgenesis, metastasis, prognosis and diagnosis. Accumulating EC-related lncRNAs have been verified to involve in various biological processes through diverse functions including signal, decoy, scaffold and guide. However, the molecular mechanism of lncRNAs in EC has not been fully explored. In this review, we outline the functions and underlying mechanism of EC-related lncRNAs to pave the way for identification of novel potential biomarkers for EC.
食管癌（EC）是全球最具侵袭性的癌症类型之一。然而，EC潜在的基因组事件尚未完全明确。越来越明显的是，长链非编码RNA（lncRNAs）在肿瘤发生、转移、预后及诊断中发挥着至关重要的作用。越来越多与EC相关的lncRNAs已被证实通过信号、诱饵、支架和引导等多种功能参与各种生物学过程。然而，lncRNAs在EC中的分子机制尚未得到充分探索。在本综述中，我们概述了与EC相关的lncRNAs的功能及潜在机制，为鉴定EC新的潜在生物标志物铺平道路。
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