Department of the 2nd Department of Thoracic Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People's Republic of China.
Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People's Republic of China.
J Hematol Oncol. 2018 Sep 17;11(1):118. doi: 10.1186/s13045-018-0663-8.
Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in the poor prognosis of EC. In addition, the underlying molecular mechanisms of EC development have yet to be elucidated. Accumulating evidence has demonstrated that lncRNAs play a vital role in the pathological progression of EC. LncRNAs may regulate gene expression through the recruitment of histone-modifying complexes to the chromatin and through interactions with RNAs or proteins. Recent evidence has demonstrated that the dysregulation of lncRNAs plays important roles in the proliferation, metastasis, invasion, angiogenesis, apoptosis, chemoradiotherapy resistance, and stemness of EC, which suggests potential clinical implications. In this review, we highlight the emerging roles and regulatory mechanisms of lncRNAs in the context of EC and discuss their potential clinical applications as diagnostic and prognostic biomarkers.
食管癌（EC）是全球第六大癌症相关死亡原因。缺乏早期诊断生物标志物和有效的转移和复发预后指标，导致 EC 的预后较差。此外，EC 发展的潜在分子机制尚未阐明。越来越多的证据表明，lncRNAs 在 EC 的病理进展中发挥着重要作用。lncRNAs 可以通过募集组蛋白修饰复合物到染色质上来调节基因表达，并通过与 RNA 或蛋白质相互作用来调节基因表达。最近的证据表明，lncRNAs 的失调在 EC 的增殖、转移、侵袭、血管生成、凋亡、放化疗耐药性和干细胞特性中发挥重要作用，这表明其具有潜在的临床意义。在这篇综述中，我们强调了 lncRNAs 在 EC 中的作用和调控机制，并讨论了它们作为诊断和预后生物标志物的潜在临床应用。
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