甘草中的两种小鼠体外受精激活剂。
Two activators of in vitro fertilization in mice from licorice.
作者信息
Tung Nguyen Huu, Shoyama Yukihiro, Wada Morimasa, Tanaka Hiromitsu
机构信息
Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan(2).
Molecular Biology Laboratories, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan.
出版信息
Biochem Biophys Res Commun. 2015 Nov 13;467(2):447-50. doi: 10.1016/j.bbrc.2015.09.088. Epub 2015 Sep 21.
Systems for artificial insemination have been established in some animals. However, due to limited availability of sperm and oocytes, more effective treatment methodologies are required. Recently, it was demonstrated that the rate of in vitro fertilization (IVF) in mice was improved by adding a water extract of licorice (Glycyrrhiza uralensis), but not glycyrrhizic acid, to the artificial insemination culture medium. In this study, we examined licorice extract for active compounds using bioassay-guided separation. The results indicated that isoliquiritigenin and formononetin were the active molecules in licorice that contributed to the improved rate of IVF.
一些动物已经建立了人工授精系统。然而，由于精子和卵母细胞的可用性有限，需要更有效的治疗方法。最近有研究表明，在人工授精培养基中添加甘草（Glycyrrhiza uralensis）水提取物而非甘草酸，可提高小鼠的体外受精（IVF）率。在本研究中，我们采用生物测定导向分离法研究了甘草提取物中的活性成分。结果表明，异甘草素和芒柄花素是甘草中有助于提高体外受精率的活性分子。
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