柬埔寨、中国和越南结核病治疗未成功的时间。
Time to unsuccessful tuberculosis treatment outcome, Cambodia, China, and Viet Nam.
作者信息
Hoa N B, Sokun C, Wei C, Lauritsen J M, Rieder H L
机构信息
National Tuberculosis Program, Hanoi, Viet Nam.
National Center for Tuberculosis and Leprosy Control, Phnom Penh, Cambodia.
出版信息
Public Health Action. 2012 Mar 21;2(1):15-20. doi: 10.5588/pha.11.0024.
OBJECTIVE
To determine the frequency and characteristics of patients with unsuccessful tuberculosis (TB) treatment.
METHODS
Random selection of TB case registers among all treatment units in Cambodia, two provinces in China, and Viet Nam. The data of two calendar years were analyzed to assess unsuccessful outcomes and their time of occurrence.
RESULTS
Among the 33 309 TB patients, treatment was unsuccessful in respectively 10.1%, 3.0% and 9.1% of patients in Cambodia, China and Viet Nam. The risk of death was highest in Cambodia, higher among males than females, increased with age, and was more common among retreatment cases than new cases, and among patients with a high than a low sputum smear microscopy grade. Half of all deaths occurred in the first 2 months in Cambodia and within 11 weeks in China and Viet Nam. Median time to default was 3 months in Cambodia and Viet Nam, and about 2 months in China.
CONCLUSIONS
Treatment was highly successful in the three study countries, with a low proportion of death and default. As the majority of defaulting occurs at the beginning of treatment, all countries should critically review their current policy of treatment support in this period.
目的
确定结核病治疗失败患者的频率及特征。
方法
在柬埔寨、中国两个省份以及越南的所有治疗单位中随机选取结核病病例登记册。对两个日历年的数据进行分析，以评估治疗失败的结果及其发生时间。
结果
在33309例结核病患者中，柬埔寨、中国和越南的治疗失败率分别为10.1%、3.0%和9.1%。柬埔寨的死亡风险最高，男性高于女性，随年龄增长而增加，复治病例比新发病例更常见，痰涂片显微镜检查分级高的患者比分级低的患者更常见。柬埔寨所有死亡病例的一半发生在最初2个月内，中国和越南则在11周内。柬埔寨和越南的中位失访时间为3个月，中国约为2个月。
结论
在这三个研究国家，治疗成功率很高，死亡和失访比例较低。由于大多数失访发生在治疗开始时，所有国家都应严格审查其当前在此期间的治疗支持政策。
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