多发性硬化症：眼动障碍综述及疾病修正疗法的更新
Multiple sclerosis: review of eye movement disorders and update of disease-modifying therapies.
作者信息
Amezcua Lilyana, Morrow Mark J, Jirawuthiworavong Guy V
机构信息
aDepartment of Neurology, University of Southern California, Keck School of Medicine, Los Angeles bDepartment of Neurology, Harbor-University of California, Los Angeles Medical Center, Torrance cDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles dDepartment of Ophthalmology, Southern California Permanente Medical Group, La Palma, California, USA.
出版信息
Curr Opin Ophthalmol. 2015 Nov;26(6):534-9. doi: 10.1097/ICU.0000000000000211.
PURPOSE OF REVIEW
To review important eye movement disorders in multiple sclerosis (MS) and update the ophthalmologist on disease-modifying therapies in MS, from the perspective of expert neurologists.
RECENT FINDINGS
A large study confirmed that eye movement abnormalities in MS can be commonly identified by bedside examination. Identifying such ocular motility disturbances can assist in the diagnosis and prognosis for patients with MS. Articles published on such agents as oral teriflunomide and the biologics, natalizumab and alemtuzumab, have defined emerging roles of these treatments in the management of MS.
SUMMARY
Many patients with MS suffer from isolated or a combination of eye movement disorders. Understanding their ocular motility disturbance patterns can help diagnose MS and correlate with the progression of MS. Exciting advances in MS disease-modifying treatments have been developed. Patients have more options than ever before of injectable, infusion and oral therapies. The therapeutic efficacy in lowering relapse rates is counterbalanced by these drugs' side-effects.
综述目的
从专家神经科医生的角度，回顾多发性硬化症（MS）中重要的眼球运动障碍，并向眼科医生介绍MS疾病修正治疗的最新情况。
最新发现
一项大型研究证实，MS中的眼球运动异常通常可通过床边检查识别。识别此类眼球运动障碍有助于MS患者的诊断和预后。关于口服特立氟胺以及生物制剂那他珠单抗和阿仑单抗等药物的文章，已明确了这些治疗方法在MS管理中的新作用。
总结
许多MS患者患有孤立的或多种眼球运动障碍。了解他们的眼球运动障碍模式有助于诊断MS并与MS的进展相关联。MS疾病修正治疗已取得令人兴奋的进展。患者有比以往更多的注射、输液和口服治疗选择。这些药物降低复发率的治疗效果被其副作用所抵消。
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