Winterhalter Sibylle, Stuebiger Nicole, Maier Anna-Karina, Pleyer Uwe, Heiligenhaus Arnd, Mackensen Friederike, Zierhut Manfred, Joussen Antonia M, Ness Thomas
a Department of Ophthalmology , Campus Virchow-Klinikum, Charité University Medicine Berlin , Berlin , Germany .
b Department of Ophthalmology , St Franziskus Hospital of Muenster, University of Duisburg Essen , Essen , Germany .
Ocul Immunol Inflamm. 2016 Oct;24(5):537-43. doi: 10.3109/09273948.2015.1034375. Epub 2015 Sep 23.
To analyze the preferred practice respective diagnosis, treatment, and complications in patients with acute retinal necrosis in Germany.
The uveitis-section of the German Ophthalmologic Society developed a questionnaire with 12 questions concerning patients with acute retinal necrosis seen in the 5 years up to August 2009.
In total, 35 eye hospitals answered the questionnaire and reported 213 patients with acute retinal necrosis. Diagnosis was made clinically in 86%. Anterior chamber tap, vitreous biopsy, diagnostic vitrectomy, and serology were performed for confirmation. Therapy was started with acyclovir in all institutions, and continued with ganciclovir, foscarnet and brivudine in some cases. Intravitreal injections were performed in 46%. Additional oral steroids were given in 80%. A following oral antiviral treatment was performed in 94%.
Relevant variations were seen in diagnosis and treatment practices. The survey outlines the need for a unique diagnostic and therapeutic guideline.
分析德国急性视网膜坏死患者在诊断、治疗及并发症方面的首选治疗方法。
德国眼科学会葡萄膜炎分会设计了一份包含12个问题的调查问卷，涉及截至2009年8月的5年中所诊治的急性视网膜坏死患者。
共有35家眼科医院回复了调查问卷，报告了213例急性视网膜坏死患者。86%的病例通过临床诊断。进行前房穿刺、玻璃体活检、诊断性玻璃体切割术及血清学检查以确诊。所有机构均以阿昔洛韦开始治疗，部分病例后续继续使用更昔洛韦、膦甲酸和溴夫定。46%的患者接受了玻璃体腔内注射。80%的患者额外给予了口服类固醇。94%的患者进行了后续口服抗病毒治疗。
在诊断和治疗方法上存在显著差异。该调查概述了制定统一诊断和治疗指南的必要性。
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