From Locus Association to Mechanism of Gene Causality: The Devil Is in the Details.
作者信息
Miller Clint L, Pjanic Milos, Quertermous Thomas
机构信息
Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, 300 Pasteur Drive, Stanford CA 94305.
出版信息
Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2079-2080. doi: 10.1161/ATVBAHA.115.306366.
Abstract
摘要
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2
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Nature. 2015 Jul 23;523(7561):486-90. doi: 10.1038/nature14590. Epub 2015 Jun 17.
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Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.冠心病相关的TCF21变异破坏了一个miR-224结合位点以及miRNA介导的调控。
PLoS Genet. 2014 Mar 27;10(3):e1004263. doi: 10.1371/journal.pgen.1004263. eCollection 2014 Mar.
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Large-scale association analysis identifies new risk loci for coronary artery disease.大规模关联分析确定了冠心病的新风险位点。
Nat Genet. 2013 Jan;45(1):25-33. doi: 10.1038/ng.2480. Epub 2012 Dec 2.
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