叶牵牛对印楝油诱导的雄性白化不育大鼠精子密度的改善作用
Improvement of sperm density in neem-oil induced infertile male albino rats by Ipomoea digitata Linn.
作者信息
Mahajan Ghanashyam Keshav, Mahajan Raghunath Totaram, Mahajan Arun Y
机构信息
Department of Zoology, Dhanaji Nana Mahavidyalaya, Faizpur, Jalgaon, Maharashtra, India.
出版信息
J Intercult Ethnopharmacol. 2015 Apr-Jun;4(2):125-8. doi: 10.5455/jice.20150103033056. Epub 2015 Jan 15.
AIM
Investigation has been carried out to validate folkloric claim of the potential of Ipomoea digitata (ID) based on reproductive health status in experimentally induced male albino rats.
MATERIALS AND METHODS
Emulsified neem oil fed albino rats were orally administered root powder of ID suspended in water for the doses of 250 and 500 mg/kg body weight for 40 days. Change in organ weight, sperm density and motility, serum hormonal levels and histomorphological changes were evaluated.
RESULTS
Significant increase in the sperm density and the sperm motility (P < 0.01) along with increase in the testis, and epididymes weight in neem-oil induced infertile rats treated with ID at both dose levels. This effect is vis-à-vis to serum hormonal levels. Presence of β-sitosterol in the root of ID likely to enhance the process of spermatogenesis as it is evident from histomorphological studies.
CONCLUSION
Results of the present investigation reveal that ID is a good candidate for the management of male infertility.
目的
基于实验诱导的雄性白化大鼠的生殖健康状况，开展研究以验证关于掌叶牵牛（ID）潜力的民间说法。
材料与方法
给喂食乳化印楝油的白化大鼠口服悬浮于水中的ID根粉，剂量为250和500毫克/千克体重，持续40天。评估器官重量、精子密度和活力、血清激素水平以及组织形态学变化。
结果
在两个剂量水平下，用ID治疗的印楝油诱导的不育大鼠的精子密度和精子活力显著增加（P < 0.01），同时睾丸和附睾重量增加。这种效应与血清激素水平相关。从组织形态学研究中可以明显看出，ID根中存在的β-谷甾醇可能会增强精子发生过程。
结论
本研究结果表明，ID是治疗男性不育的良好候选药物。
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