Hussain Saad Abdulrahman, Alzubaidi Fatima Adnan, Hashem Hayder Obayes
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
Department of Pharmacology, College of Pharmacy, University of Babylon, Babylon, Iraq.
J Intercult Ethnopharmacol. 2015 Jul-Sep;4(3):234-8. doi: 10.5455/jice.20150628102732. Epub 2015 Jun 30.
There are many concerns about the interactions of herbal products with conventional drugs, which are mostly used as multiple drug treatment approach. The present study was designed to evaluate the effect of long-term use of Ginkgo biloba extract (GK) on the absorption and tissue distribution of fluoxetine and venlafaxine.
46 Wistar rats are utilized and allocated into 8 groups; 2 groups administered the vehicle and saved as control; 4 groups are treated with 100 and 200 mg/kg of GK extract for 30 days; 2 groups are treated with 40 mg/kg verapamil for 10 days. The liver, kidney, and brain distribution of fluoxetine and venlafaxine were evaluated after single oral doses using high performance liquid chromatographic method.
200 mg/kg GK increases fluoxetine concentrations in all studied organs, while GK 100 mg/kg increases venlafaxine levels in kidney tissue and not affected in the other two organs.
Thirty days treatment with GK (100 mg/kg) increases kidney availability of venlafaxine, while 200 mg GK dose increases fluoxetine availability in the liver, kidney, and brain tissues after single oral doses.
草药产品与传统药物的相互作用引发了诸多关注，传统药物大多采用多种药物联合治疗的方法。本研究旨在评估长期使用银杏叶提取物（GK）对氟西汀和文拉法辛吸收及组织分布的影响。
选用46只Wistar大鼠，分为8组；2组给予赋形剂作为对照；4组分别用100和200mg/kg的GK提取物处理30天；2组用40mg/kg维拉帕米处理10天。采用高效液相色谱法，在单次口服给药后评估氟西汀和文拉法辛在肝脏、肾脏和大脑中的分布情况。
200mg/kg的GK可提高所有研究器官中氟西汀的浓度，而100mg/kg的GK可提高肾脏组织中文拉法辛的水平，对其他两个器官无影响。
GK（100mg/kg）治疗30天可提高文拉法辛在肾脏中的可用性，而200mg GK剂量可提高单次口服给药后氟西汀在肝脏、肾脏和脑组织中的可用性。
