Hussain Saad Abdulrahman, Sulaiman Amal Ajaweed, Alhaddad Hasan, Alhadidi Qasim
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH, 43614, USA.
J Intercult Ethnopharmacol. 2016 Jan 27;5(1):97-104. doi: 10.5455/jice.20160118062127. eCollection 2016 Jan-Feb.
Accumulated evidence has focused on the use of natural polyphenolic compounds as nutraceuticals since they showed a wide range of bioactivities and exhibited protection against variety of age-related disorders. Polyphenols have variable potencies to interact, and hence alter the activities of various transporter proteins, many of them classified as anion transporting polypeptide-binding cassette transporters like multidrug resistance protein and p-glycoprotein. Some of the efflux transporters are, generally, linked with anticancer and antiviral drug resistance; in this context, polyphenols may be beneficial in modulating drug resistance by increasing the efficacy of anticancer and antiviral drugs. In addition, these effects were implicated to explain the influence of dietary polyphenols on drug efficacy as result of food-drug interactions. However, limited data are available about the influence of these components on uptake transporters. Therefore, the objective of this article is to review the potential efficacies of polyphenols in modulating the functional integrity of uptake transporter proteins, including those terminated the effect of neurotransmitters, and their possible influence in neuropharmacology.
越来越多的证据表明，天然多酚类化合物具有广泛的生物活性，能预防多种与年龄相关的疾病，因此可作为营养保健品使用。多酚类物质具有不同的相互作用能力，从而改变各种转运蛋白的活性，其中许多转运蛋白被归类为阴离子转运多肽结合盒转运蛋白，如多药耐药蛋白和P-糖蛋白。一些外排转运蛋白通常与抗癌和抗病毒药物耐药性有关；在这种情况下，多酚类物质可能通过提高抗癌和抗病毒药物的疗效来调节耐药性，从而发挥有益作用。此外，这些作用被认为可以解释饮食中的多酚类物质通过食物-药物相互作用对药物疗效的影响。然而，关于这些成分对摄取转运蛋白影响的数据有限。因此，本文的目的是综述多酚类物质在调节摄取转运蛋白功能完整性方面的潜在功效，包括那些终止神经递质作用的转运蛋白，以及它们在神经药理学中的可能影响。
