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印度儿童单侧先天性和发育性白内障:手术的长期效果如何?米拉杰儿童白内障研究4

Unilateral Congenital and Developmental Cataracts in Children in India: How Useful Were Long-Term Outcomes of Surgery? Miraj Pediatric Cataract Study 4.

作者信息

Gogate Parikshit, Patil Shailbala, Kulkarni Anil, Sahasrabudhe Mohini, Shah Mitali, Mahadik Ashok, Sane Srivallabh, Bhasa Divya

机构信息

From the *Lions NAB Eye Hospital, Miraj; †Dr. Gogate's Eye Clinic, Pune; ‡Dr. Kulkarni Eye Hospital, Miraj; §Bharati Vidyapeeth Medical College, Sangli; and ¶Data Clinic, Pune, India.

出版信息

Asia Pac J Ophthalmol (Phila). 2015 Nov-Dec;4(6):376-80. doi: 10.1097/APO.0000000000000132.

DOI:10.1097/APO.0000000000000132
PMID:26401649
Abstract

PURPOSE

To study visual outcomes and stereopsis after a 3-8 year follow-up in unilateral congenital and developmental cataracts.

DESIGN

Clinical case series.

METHODS

Children who underwent surgery for unilateral pediatric cataract from 2004 to 2008 were traced and reexamined prospectively from 2010 to 2011. Demographic and clinical factors were noted from their retrospective chart readings. All children underwent visual acuity assessment and comprehensive ocular examinations including stereoacuity in a standardized manner during the prospective follow-up visits. Details of amblyopia management were recorded for univariate and multivariate analyses.

RESULTS

Forty-eight eyes of 48 children had a mean follow-up of 4.4 years between surgery and assessment (SD, 1.6 years). Twenty-four (50%) were boys, and the average age at surgery was 10.2 years (SD, 4.1). Two (4.2%) were congenital, 14 (29.2%) developmental, and 32 (66.7%) congenital/developmental cataracts. Preoperatively, 38 (79.2%) had vision less than 3/60. After surgery, 12 (25%) had improved best-corrected visual acuity (BCVA) of 6/18 or greater, 4 (8.3%) had BCVA of 6/24 to 6/60, and 32 (66.7%) had BCVA of less than 6/60. Eleven (22.9%) had binocular single vision 480 seconds or less of arc on Titmus test. Preoperative vision (P = 0.034) was significantly associated with postoperative visual outcomes, but not age at surgery (P = 0.14), sex (P = 0.897), type of surgery (P = 0.371), or type of intraocular lens (P = 0.66). The use of phacoemulsification was associated with better vision, but it was not significant (P = 0.069).

CONCLUSIONS

Long-term visual outcomes in unilateral pediatric cataracts were subnormal due to deprivation amblyopia, but vision improved over preoperative levels and helped in binocular stereoacuity. Some preoperative vision was associated with better visual outcomes.

摘要

目的

研究单侧先天性和发育性白内障患者在3 - 8年随访后的视力结果和立体视。

设计

临床病例系列。

方法

对2004年至2008年接受单侧小儿白内障手术的儿童进行追踪,并于2010年至2011年进行前瞻性复查。通过回顾病历记录人口统计学和临床因素。在进行前瞻性随访时,所有儿童均接受视力评估和包括立体视锐度在内的全面眼部检查,且检查方式标准化。记录弱视治疗的详细情况以进行单因素和多因素分析。

结果

48名儿童的48只眼在手术和评估之间的平均随访时间为4.4年(标准差为1.6年)。其中24名(50%)为男孩,手术时的平均年龄为10.2岁(标准差为4.1)。2只眼(4.2%)为先天性白内障,14只眼(29.2%)为发育性白内障,32只眼(66.7%)为先天性/发育性白内障。术前,38只眼(79.2%)视力低于3/60。术后,12只眼(25%)最佳矫正视力(BCVA)提高到6/18或更好,4只眼(8.3%)BCVA为6/24至6/60,32只眼(66.7%)BCVA低于6/60。11只眼(22.9%)在Titmus测试中双眼单视小于或等于480秒弧度。术前视力(P = 0.034)与术后视力结果显著相关,但与手术年龄(P = 0.14)、性别(P = 0.897)、手术类型(P = 0.371)或人工晶状体类型(P = 0.66)无关。超声乳化手术的应用与更好的视力相关,但差异不显著(P = 0.069)。

结论

由于剥夺性弱视,单侧小儿白内障的长期视力结果低于正常水平,但视力较术前有所改善,并有助于双眼立体视。一些术前视力与更好的视力结果相关。

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