Tang Xiaoying, Holland Dominic, Dale Anders M, Miller Michael I
Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
J Alzheimers Dis. 2015;47(3):645-60. doi: 10.3233/JAD-150262.
This paper examines how age intervenes in the effects of APOE ɛ4 allele on the volume and shape morphometrics of the hippocampus and the amygdala in mild cognitive impairment (MCI) and Alzheimer's disease. We evaluate the structural morphological differences between ɛ4 carriers and non-carriers in two age-dependent subgroups; younger than 75 years (Young-Old) and older than 80 years (Very-Old). While we show that the four structures of interest atrophy significantly in the ɛ4 carriers, relative to the non-carriers, of the Young-Old group, this effect is not observed in their Very-Old counterparts. The structures in the right hemisphere are found to be more affected by the APOE genotype than those in the left hemisphere and we identify the relevant regions in which significant atrophy occurs to be parts of the basolateral, centromedial, and lateral nucleus subregions of the amygdala and the CA1 and subiculum subregions of the hippocampus. We also observe that the APOE genotype only affects MCI patients that deteriorated to dementia within 3 years while leaving their "non-converting" counterparts unaffected.
本文研究了年龄如何干预载脂蛋白E（APOE）ε4等位基因对轻度认知障碍（MCI）和阿尔茨海默病患者海马体和杏仁核体积及形态测量的影响。我们评估了两个年龄相关亚组（75岁以下的年轻老年人和80岁以上的非常老年人）中ε4携带者和非携带者之间的结构形态差异。虽然我们发现，相对于年轻老年组中的非携带者，ε4携带者的四个感兴趣结构明显萎缩，但在非常老年组中未观察到这种效应。发现右半球的结构比左半球的结构受APOE基因型的影响更大，并且我们确定发生显著萎缩的相关区域是杏仁核基底外侧、中央内侧和外侧核亚区域以及海马体CA1和下托亚区域的部分。我们还观察到，APOE基因型仅影响3年内恶化为痴呆症的MCI患者，而其“未转化”的对应患者则不受影响。
