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硬膜外麻醉能否降低接受开放性腹主动脉瘤修复术患者术后氧饱和度下降事件的发生率?

Does epidural anaesthesia reduce the incidence of postoperative oxygen desaturation episodes in patients undergoing open abdominal aortic aneurysm repair?

作者信息

Dylczyk-Sommer Joanna, Owczuk Radosław, Wujtewicz Maria, Wojciechowski Jacek

机构信息

Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Poland.

出版信息

Anaesthesiol Intensive Ther. 2015;47(4):291-6. doi: 10.5603/AIT.2015.0043.

Abstract

BACKGROUND

Postoperative desaturation can lead to severe hypoxaemia and even tissue hypoxia, followed by cardiological and neurological complications. Opioid usage is the one of the most important risk factors of postoperative desaturation and hypoxemia. Epidural anaesthesia is recommended for vascular surgery for many reasons; the reduction or elimination of opioid doses is one reason. The aims of the study were to evaluate the incidence of desaturation episodes in patients after surgical procedures with abdominal aortic clamping, to determine whether the episodes in question lead to clinical symptoms of hypoxia and to determine whether epidural anaesthesia decreases the incidence of desaturation episodes.

METHODS

After abdominal aortic repair, 58 patients who did not have any respiratory disease, were classified as ASA II-III, and were aged from 46 to 80 years were observed in the ICU during spontaneous breathing with oxygen supplementation. Non-invasive O₂ saturation measurements were taken continuously, and all desaturation incidents (defined as O₂ saturation ≤ 93% for 4 min) were noted. Patients were divided into two equal groups: A - epidural blockade used after the operation for pain relief and B - intravenous opioids administered during the postoperative period. We evaluated and compared the desaturation frequency during the postoperative period.

RESULTS

Desaturation was observed among 26 (89%) patients in group A and 27 (93%) patients in group B. There were no statistical differences among the groups (P = 1.0). Severe hypoxemia (O₂ saturation ≤ 84%) was observed among 7 (24.1%) patients in group A and 10 patients in group B (34.5%) (P = 0.38). Clinical symptoms of hypoxia were similar in both groups (P = 1.0).

CONCLUSIONS

Epidural anaesthesia did not protect against postoperative desaturation. Though oxygen therapy was used, desaturation was observed in approximately 90% of patients.

摘要

背景

术后低氧饱和度可导致严重低氧血症,甚至组织缺氧,进而引发心脏和神经并发症。阿片类药物的使用是术后低氧饱和度和低氧血症最重要的危险因素之一。出于多种原因,血管手术推荐使用硬膜外麻醉;减少或消除阿片类药物剂量是其中一个原因。本研究的目的是评估腹主动脉阻断手术后患者低氧饱和度发作的发生率,确定这些发作是否会导致缺氧的临床症状,并确定硬膜外麻醉是否会降低低氧饱和度发作的发生率。

方法

腹主动脉修复术后,58例无任何呼吸系统疾病、美国麻醉医师协会(ASA)分级为II-III级、年龄在46至80岁之间的患者在重症监护病房(ICU)接受吸氧自主呼吸观察。持续进行无创氧饱和度测量,并记录所有低氧饱和度事件(定义为氧饱和度≤93%持续4分钟)。患者被分为两组,每组人数相等:A组——术后使用硬膜外阻滞缓解疼痛;B组——术后期间静脉注射阿片类药物。我们评估并比较了术后期间的低氧饱和度频率。

结果

A组26例(89%)患者和B组27例(93%)患者出现了低氧饱和度。两组之间无统计学差异(P = 1.0)。A组7例(24.1%)患者和B组10例(34.5%)患者出现了严重低氧血症(氧饱和度≤84%)(P = 0.38)。两组缺氧的临床症状相似(P = 1.0)。

结论

硬膜外麻醉并不能预防术后低氧饱和度。尽管使用了氧疗,但约90%的患者出现了低氧饱和度。

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