脑源性神经营养因子（Val66Met）基因多态性与甲基苯丙胺依赖易感性相关。
BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence.
作者信息
Iamjan Sri-Arun, Thanoi Samur, Watiktinkorn Paritat, Nudmamud-Thanoi Sutisa, Reynolds Gavin P
机构信息
Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
出版信息
Pharmacogenomics. 2015;16(14):1541-5. doi: 10.2217/pgs.15.96. Epub 2015 Sep 24.
AIM
Association of the brain-derived neurotrophic factor (BDNF) genetic polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and METH-induced psychosis was investigated in the Thai population.
MATERIALS & METHODS: The rs6265 genotype was determined in 100 male METH-dependent subjects and 102 controls using a real-time PCR high-resolution melt (RT-PCR-HRM) assay.
RESULTS
The rs6265 genotype demonstrated significant differences in distribution between METH-dependent subjects and controls in which the frequency of GG genotype versus A-allele carriers was associated with METH dependence. Moreover, a significant effect of genotype on the occurrence of psychosis was found, with a lower frequency of GG genotype associated with METH-induced psychosis.
CONCLUSION
The present findings indicate that rs6265 is associated with METH dependence in the Thai population, with the GG genotype greater in METH-dependent subjects but reducing the emergence of METH-dependent psychosis.
目的
在泰国人群中研究脑源性神经营养因子（BDNF）基因多态性rs6265（Val66Met）与甲基苯丙胺（METH）依赖及METH所致精神病之间的关联。
材料与方法
采用实时聚合酶链反应高分辨率熔解曲线分析（RT-PCR-HRM）法，对100名男性METH依赖者和102名对照者的rs6265基因型进行检测。
结果
rs6265基因型在METH依赖者和对照者之间的分布存在显著差异，其中GG基因型与A等位基因携带者的频率与METH依赖相关。此外，发现基因型对精神病的发生有显著影响，GG基因型频率较低与METH所致精神病相关。
结论
目前的研究结果表明，rs6265与泰国人群中的METH依赖相关，GG基因型在METH依赖者中更为常见，但可降低METH依赖所致精神病的发生。
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