Iamjan Sri-Arun, Thanoi Samur, Watiktinkorn Paritat, Nudmamud-Thanoi Sutisa, Reynolds Gavin P
Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
Pharmacogenomics. 2015;16(14):1541-5. doi: 10.2217/pgs.15.96. Epub 2015 Sep 24.
Association of the brain-derived neurotrophic factor (BDNF) genetic polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and METH-induced psychosis was investigated in the Thai population.
MATERIALS & METHODS: The rs6265 genotype was determined in 100 male METH-dependent subjects and 102 controls using a real-time PCR high-resolution melt (RT-PCR-HRM) assay.
The rs6265 genotype demonstrated significant differences in distribution between METH-dependent subjects and controls in which the frequency of GG genotype versus A-allele carriers was associated with METH dependence. Moreover, a significant effect of genotype on the occurrence of psychosis was found, with a lower frequency of GG genotype associated with METH-induced psychosis.
The present findings indicate that rs6265 is associated with METH dependence in the Thai population, with the GG genotype greater in METH-dependent subjects but reducing the emergence of METH-dependent psychosis.
在泰国人群中研究脑源性神经营养因子（BDNF）基因多态性rs6265（Val66Met）与甲基苯丙胺（METH）依赖及METH所致精神病之间的关联。
采用实时聚合酶链反应高分辨率熔解曲线分析（RT-PCR-HRM）法，对100名男性METH依赖者和102名对照者的rs6265基因型进行检测。
rs6265基因型在METH依赖者和对照者之间的分布存在显著差异，其中GG基因型与A等位基因携带者的频率与METH依赖相关。此外，发现基因型对精神病的发生有显著影响，GG基因型频率较低与METH所致精神病相关。
目前的研究结果表明，rs6265与泰国人群中的METH依赖相关，GG基因型在METH依赖者中更为常见，但可降低METH依赖所致精神病的发生。
