• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[18F]-氟化钠正电子发射断层显像/计算机断层扫描成像在心脏淀粉样变中的应用

[18F]-NaF PET/CT imaging in cardiac amyloidosis.

作者信息

Van Der Gucht Axel, Galat Arnault, Rosso Jean, Guellich Aziz, Garot Jérôme, Bodez Diane, Plante-Bordeneuve Violaine, Hittinger Luc, Dubois-Randé Jean-Luc, Evangelista Eva, Sasanelli Myriam, Chalaye Julia, Meignan Michel, Itti Emmanuel, Damy Thibaud

机构信息

UPEC, AP-HP Henri-Mondor Teaching Hospital, 94000, Créteil, France.

Mondor Amyloidosis Network, 94000, Créteil, France.

出版信息

J Nucl Cardiol. 2016 Aug;23(4):846-9. doi: 10.1007/s12350-015-0287-0. Epub 2015 Sep 24.

DOI:10.1007/s12350-015-0287-0
PMID:26403145
Abstract

Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.

摘要

心脏淀粉样变性（CA）被认为是限制性心肌病和心力衰竭的常见原因，这是由于不溶性蛋白质沉积在心肌间质中所致。我们强调[18F] - 氟化钠（NaF）PET/CT作为一种潜在的非侵入性工具在识别和区分转甲状腺素蛋白相关的心脏淀粉样变性与轻链心脏淀粉样变性方面的作用。我们报告了两例病例，一名73岁男性和一名75岁女性，分别因家族性转甲状腺素蛋白Val122Ile心脏淀粉样变性和轻链心脏淀粉样变性在我们中心接受充血性心力衰竭治疗，左心室射血分数有明显改变，经心内膜活检确诊。

相似文献

1
[18F]-NaF PET/CT imaging in cardiac amyloidosis.[18F]-氟化钠正电子发射断层显像/计算机断层扫描成像在心脏淀粉样变中的应用
J Nucl Cardiol. 2016 Aug;23(4):846-9. doi: 10.1007/s12350-015-0287-0. Epub 2015 Sep 24.
2
Examining the sensitivity of 18F-NaF PET for the imaging of cardiac amyloidosis.检测 18F-NaF PET 对心脏淀粉样变性成像的敏感性。
J Nucl Cardiol. 2021 Feb;28(1):209-218. doi: 10.1007/s12350-019-01675-2. Epub 2019 Mar 4.
3
Discordant Findings on 18F-NaF and 99mTc-HDP Bone Scans in a Patient With ATTR Cardiac Amyloidosis.ATTR 心脏淀粉样变性患者 18F-NaF 和 99mTc-HDP 骨扫描结果不一致。
Clin Nucl Med. 2018 Mar;43(3):e89-e92. doi: 10.1097/RLU.0000000000001933.
4
Does the etiology of cardiac amyloidosis determine the myocardial uptake of [18F]-NaF PET/CT?心脏淀粉样变性的病因是否决定了[18F]-氟化钠正电子发射断层显像/计算机断层扫描（PET/CT）的心肌摄取？
J Nucl Cardiol. 2017 Apr;24(2):746-749. doi: 10.1007/s12350-016-0457-8. Epub 2016 Mar 14.
5
Diagnostic performance of PET for detection of cardiac amyloidosis: A systematic review and meta-analysis.PET 诊断心脏淀粉样变性的性能：系统评价和荟萃分析。
J Cardiol. 2020 Dec;76(6):618-625. doi: 10.1016/j.jjcc.2020.07.003. Epub 2020 Jul 15.
6
F-sodium fluoride PET/MRI myocardial imaging in patients with suspected cardiac amyloidosis.氟[18F]去铁胺 PET/MRI 心肌显像在疑似心脏淀粉样变性患者中的应用。
J Nucl Cardiol. 2021 Aug;28(4):1586-1595. doi: 10.1007/s12350-019-01885-8. Epub 2019 Sep 11.
7
Comparison of 18F-sodium fluoride positron emission tomography imaging and 99mTc-pyrophosphate in cardiac amyloidosis.18F-氟化钠正电子发射断层扫描成像与 99mTc-焦磷酸盐在心脏淀粉样变性中的比较。
J Nucl Cardiol. 2022 Jun;29(3):1132-1140. doi: 10.1007/s12350-020-02425-5. Epub 2020 Nov 4.
8
Fluorine sodium fluoride positron emission tomography, a potential biomarker of transthyretin cardiac amyloidosis.氟[18F]去铁胺正电子发射断层扫描，转甲状腺素蛋白心脏淀粉样变的一个潜在生物标志物。
J Nucl Cardiol. 2018 Oct;25(5):1559-1567. doi: 10.1007/s12350-017-0799-x. Epub 2017 Feb 7.
9
Analysis of F-Sodium Fluoride Positron Emission Tomography Signal Sources in Atherosclerotic Minipigs Shows Specific Binding of F-Sodium Fluoride to Plaque Calcifications.分析动脉粥样硬化小型猪的 F-氟化钠正电子发射断层扫描信号来源显示 F-氟化钠与斑块钙化的特异性结合。
Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):e480-e490. doi: 10.1161/ATVBAHA.121.316075. Epub 2021 Jul 22.
10
[18F]-Florbetaben PET/CT for Differential Diagnosis Among Cardiac Immunoglobulin Light Chain, Transthyretin Amyloidosis, and Mimicking Conditions.[18F]-氟硼替苯 PET/CT 用于心脏免疫球蛋白轻链、转甲状腺素蛋白淀粉样变性和类似疾病的鉴别诊断。
JACC Cardiovasc Imaging. 2021 Jan;14(1):246-255. doi: 10.1016/j.jcmg.2020.05.031. Epub 2020 Aug 5.

引用本文的文献

1
Positron emission tomography in cardiac amyloidosis: current evidence and future directions.心脏淀粉样变的正电子发射断层扫描：当前证据与未来方向。
Heart Fail Rev. 2025 May;30(3):605-618. doi: 10.1007/s10741-025-10493-3. Epub 2025 Feb 10.
2
Microcalcification and Tc-Pyrophosphate Uptake without Increased Bone Metabolism in Cardiac Tissue from Patients with Transthyretin Cardiac Amyloidosis.心肌转甲状腺素蛋白心脏淀粉样变患者心脏组织中无微钙化和 Tc-焦磷酸盐摄取而无骨代谢增加。
Int J Mol Sci. 2023 Jan 18;24(3):1921. doi: 10.3390/ijms24031921.
3
F-Sodium Fluoride (NaF) Uptake in Calcified Bladder Carcinoma: Double Density Sign.

本文引用的文献

1
Usefulness of (99m)Tc-HMDP scintigraphy for the etiologic diagnosis and prognosis of cardiac amyloidosis.(99m)Tc-HMDP 闪烁显像用于心脏淀粉样变性的病因诊断和预后判断的价值。
Amyloid. 2015;22(4):210-20. doi: 10.3109/13506129.2015.1072089. Epub 2015 Oct 14.
2
Bone scintigraphy with (99m)technetium-hydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis.锝[99mTc]羟甲基二膦酸盐骨闪烁扫描术可早期诊断转甲状腺素蛋白衍生的系统性淀粉样变患者的心脏受累。
Amyloid. 2014 Mar;21(1):35-44. doi: 10.3109/13506129.2013.871250. Epub 2014 Jan 23.
3
钙化性膀胱癌中氟代硫酸钠（NaF）摄取：双密度征
Mol Imaging Radionucl Ther. 2021 Oct 15;30(3):190-192. doi: 10.4274/mirt.galenos.2020.87699.
4
Cardiac hybrid imaging: novel tracers for novel targets.心脏混合成像：针对新靶点的新型示踪剂。
J Geriatr Cardiol. 2021 Sep 28;18(9):748-758. doi: 10.11909/j.issn.1671-5411.2021.09.006.
5
Multimodality Imaging in the Evaluation and Management of Cardiac Amyloidosis.心脏淀粉样变评估与管理中的多模态成像
Semin Nucl Med. 2020 Jul;50(4):295-310. doi: 10.1053/j.semnuclmed.2020.01.001. Epub 2020 Feb 9.
6
Update of the Brazilian Guideline on Nuclear Cardiology - 2020.《巴西核心脏病学指南（2020年版）》更新
Arq Bras Cardiol. 2020 Feb;114(2):325-429. doi: 10.36660/abc.20200087.
7
Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis.专家共识建议：疑似转甲状腺素蛋白心脏淀粉样变性的诊断。
Circ Heart Fail. 2019 Sep;12(9):e006075. doi: 10.1161/CIRCHEARTFAILURE.119.006075. Epub 2019 Sep 4.
8
ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2-evidence base and standardized methods of imaging.美国核医学与分子影像学会/美国心脏协会/美国超声心动图学会/欧洲核医学协会/美国心力衰竭学会/美国心律学会/心血管磁共振学会/美国核医学与分子影像学会关于心脏淀粉样变性多模态成像的专家共识建议：第1部分——证据基础和标准化成像方法
J Nucl Cardiol. 2019 Dec;26(6):2065-2123. doi: 10.1007/s12350-019-01760-6.
9
Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), previously known as senile cardiac amyloidosis: clinical presentation, diagnosis, management and emerging therapies.野生型转甲状腺素蛋白心脏淀粉样变性（ATTRwt-CA），以前称为老年心脏淀粉样变性：临床表现、诊断、管理及新兴疗法。
J Thorac Dis. 2018 Mar;10(3):2034-2045. doi: 10.21037/jtd.2018.03.134.
10
Can Nuclear Imaging Techniques Predict Patient Outcome and Guide Medical Management in Hereditary Transthyretin Cardiac Amyloidosis?核医学成像技术能否预测遗传性转甲状腺素蛋白心脏淀粉样变患者的预后并指导医学管理？
Curr Cardiol Rep. 2018 Mar 24;20(5):33. doi: 10.1007/s11886-018-0976-9.
Role of (99m)Tc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis.
(99m)Tc-DPD 闪烁显像在遗传性转甲状腺素蛋白相关心脏淀粉样变性的诊断和预后中的作用。
JACC Cardiovasc Imaging. 2011 Jun;4(6):659-70. doi: 10.1016/j.jcmg.2011.03.016.
4
Uptake of technetium 99m HDP in cardiac amyloidosis.锝99m HDP在心脏淀粉样变中的摄取情况。
Int J Cardiovasc Imaging. 2003 Jun;19(3):225-7. doi: 10.1023/a:1023608115278.
5
Uptake of technetium-99m MDP in primary amyloidosis with a review of the mechanisms of soft tissue localization of bone seeking radiopharmaceuticals.
J Nucl Med. 1993 Sep;34(9):1612-5.