Van Der Gucht Axel, Galat Arnault, Rosso Jean, Guellich Aziz, Garot Jérôme, Bodez Diane, Plante-Bordeneuve Violaine, Hittinger Luc, Dubois-Randé Jean-Luc, Evangelista Eva, Sasanelli Myriam, Chalaye Julia, Meignan Michel, Itti Emmanuel, Damy Thibaud
UPEC, AP-HP Henri-Mondor Teaching Hospital, 94000, Créteil, France.
Mondor Amyloidosis Network, 94000, Créteil, France.
J Nucl Cardiol. 2016 Aug;23(4):846-9. doi: 10.1007/s12350-015-0287-0. Epub 2015 Sep 24.
Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.
心脏淀粉样变性（CA）被认为是限制性心肌病和心力衰竭的常见原因，这是由于不溶性蛋白质沉积在心肌间质中所致。我们强调[18F] - 氟化钠（NaF）PET/CT作为一种潜在的非侵入性工具在识别和区分转甲状腺素蛋白相关的心脏淀粉样变性与轻链心脏淀粉样变性方面的作用。我们报告了两例病例，一名73岁男性和一名75岁女性，分别因家族性转甲状腺素蛋白Val122Ile心脏淀粉样变性和轻链心脏淀粉样变性在我们中心接受充血性心力衰竭治疗，左心室射血分数有明显改变，经心内膜活检确诊。
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