Gagliardi Christian, Tabacchi Elena, Bonfiglioli Rachele, Diodato Stefania, Nanni Cristina, Guidalotti Pierluigi, Lorenzini Massimiliano, Lodi Filippo, Milandri Agnese, Rapezzi Claudio, Fanti Stefano
Cardio-Thoraco-Vascular Department, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
Nuclear Medicine Unit, DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
J Nucl Cardiol. 2017 Apr;24(2):746-749. doi: 10.1007/s12350-016-0457-8. Epub 2016 Mar 14.
Cardiac amyloidosis (CA) leads to variable degrees of myocardial infiltration with a final echocardiographic phenotype of "hypertrophy." Although many non-invasive imaging techniques (MRI, CT, scintigraphy, PET) are useful, the definitive diagnosis is still based on myocardial histology. We explored the possible role of [18F]-NaF PET/CT in the diagnosis of this disease in two cases with wild-type (ATTRwt) or mutant (ATTRm) Ile68Leu transthyretin (TTR)-related CA.
心脏淀粉样变性（CA）会导致不同程度的心肌浸润，最终的超声心动图表现为“肥厚”。尽管许多非侵入性成像技术（MRI、CT、闪烁扫描、PET）都很有用，但确诊仍基于心肌组织学。我们探讨了[18F]-氟化钠PET/CT在两例野生型（ATTRwt）或突变型（ATTRm）Ile68Leu转甲状腺素蛋白（TTR）相关CA患者中对该病诊断的可能作用。
