Deng Shunzhou, Martin Carly, Patil Rasika, Zhu Felix, Zhao Bin, Xiang Zuoshuang, He Yongqun
Department of Veterinary Medicine, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
Vaccine. 2015 Nov 27;33(48):6938-46. doi: 10.1016/j.vaccine.2015.07.113. Epub 2015 Sep 25.
A recombinant vector vaccine uses an attenuated virus, bacterium, or parasite as the carrier to express a heterologous antigen(s). Many recombinant vaccine vectors and related vaccines have been developed and extensively investigated. To compare and better understand recombinant vectors and vaccines, we have generated Vaxvec (http://www.violinet.org/vaxvec), the first web-based database that stores various recombinant vaccine vectors and those experimentally verified vaccines that use these vectors. Vaxvec has now included 59 vaccine vectors that have been used in 196 recombinant vector vaccines against 66 pathogens and cancers. These vectors are classified to 41 viral vectors, 15 bacterial vectors, 1 parasitic vector, and 1 fungal vector. The most commonly used viral vaccine vectors are double-stranded DNA viruses, including herpesviruses, adenoviruses, and poxviruses. For example, Vaxvec includes 63 poxvirus-based recombinant vaccines for over 20 pathogens and cancers. Vaxvec collects 30 recombinant vector influenza vaccines that use 17 recombinant vectors and were experimentally tested in 7 animal models. In addition, over 60 protective antigens used in recombinant vector vaccines are annotated and analyzed. User-friendly web-interfaces are available for querying various data in Vaxvec. To support data exchange, the information of vaccine vectors, vaccines, and related information is stored in the Vaccine Ontology (VO). Vaxvec is a timely and vital source of vaccine vector database and facilitates efficient vaccine vector research and development.
重组载体疫苗使用减毒病毒、细菌或寄生虫作为载体来表达异源抗原。许多重组疫苗载体及相关疫苗已被研发并广泛研究。为了比较并更好地理解重组载体和疫苗，我们创建了Vaxvec（http://www.violinet.org/vaxvec），这是首个基于网络的数据库，存储各种重组疫苗载体以及那些经实验验证的使用这些载体的疫苗。Vaxvec现已收录了59种疫苗载体，这些载体已被用于196种针对66种病原体和癌症的重组载体疫苗中。这些载体分为41种病毒载体、15种细菌载体、1种寄生虫载体和1种真菌载体。最常用的病毒疫苗载体是双链DNA病毒，包括疱疹病毒、腺病毒和痘病毒。例如，Vaxvec收录了63种基于痘病毒的针对多种病原体和癌症的重组疫苗。Vaxvec收集了30种使用17种重组载体并在7种动物模型中进行过实验测试的重组载体流感疫苗。此外，还对重组载体疫苗中使用的60多种保护性抗原进行了注释和分析。提供了用户友好的网络界面来查询Vaxvec中的各种数据。为了支持数据交换，疫苗载体、疫苗及相关信息存储在疫苗本体（VO）中。Vaxvec是一个及时且重要的疫苗载体数据库资源，有助于高效的疫苗载体研发。
