Chai Minghan, Su Shili, Dong Baihua
Department of Gynecology and Obstetrics, Qilu Hospital, Shandong University, 107#, West Wenhua Road, Jinan, 250012 China.
J Obstet Gynaecol India. 2015 Oct;65(5):323-7. doi: 10.1007/s13224-014-0620-6. Epub 2014 Oct 29.
To study the effect of low-dose levonorgestrel contraceptive intrauterine systems (LNG-IUS-12) on endometrial morphology and ultrastructure.
Twenty seven women who desired contraception were inserted LNG-IUS-12. Endometrial biopsies were collected during the late proliferative phase of the cycle before (control) and after the use of the LNG-IUS for 36 months. The changes of morphology and ultrastructure of endometrium tissue were observed by light microscope and transmission electron microscope.
After 36 months of use, the endometrial gland reduced in number and some were atrophic. A decidual change of stroma was present. Electronic microscopy demonstrated the presence of low columnar, karyopyknosis, and chromatin margination in the glandular epithelial cell. Some vacuolar degeneration in partial mitochondria and rough endoplasmic reticulum presented light extension. Changes could be concluded as cell inhibition of proliferation.
The low-dose levonorgestrel-releasing intrauterine systems has a suppressive effect on endometrium that is similar to LNG-IUS.
研究低剂量左炔诺孕酮宫内节育系统（LNG-IUS-12）对子宫内膜形态及超微结构的影响。
选取27例有避孕需求的女性，放置LNG-IUS-12。在放置前（对照）及使用LNG-IUS 36个月后的月经周期增殖晚期采集子宫内膜活检标本。通过光学显微镜和透射电子显微镜观察子宫内膜组织形态及超微结构的变化。
使用36个月后，子宫内膜腺体数量减少，部分腺体萎缩。间质出现蜕膜样变。电子显微镜显示腺上皮细胞呈低柱状、核固缩及染色质边集。部分线粒体和粗面内质网出现轻度扩张的空泡样变性。变化可归结为细胞增殖抑制。
低剂量左炔诺孕酮宫内节育系统对子宫内膜具有与LNG-IUS相似的抑制作用。
