简讯：CRISPR-RNA引导的适应性免疫系统。
SnapShot: CRISPR-RNA-guided adaptive immune systems.
作者信息
Carter Joshua, Wiedenheft Blake
机构信息
Montana State University, Department of Microbiology and Immunology, Bozeman, MT 59715, USA.
出版信息
Cell. 2015 Sep 24;163(1):260-260.e1. doi: 10.1016/j.cell.2015.09.011.
Abstract
Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This SnapShot summarizes our current knowledge of these fascinating immune systems.
摘要
细菌和古生菌已经进化出复杂的适应性免疫系统，该系统依赖于成簇规律间隔短回文重复序列（CRISPR）位点以及多种Cas基因组成的元件盒，这些Cas基因被分为三种主要类型和至少十一个亚型。所有CRISPR-Cas免疫系统都通过三个主要阶段运行：获取、生物合成和干扰。本简要概述总结了我们目前对这些迷人免疫系统的了解。
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