Maan Muhammad Kashif, Weng Zhifei, Dai Menghong, Liu Zhenli, Hao Haihong, Cheng Guyue, Wang Yulian, Wang Xu, Huang Lingli
National Reference Laboratory of Veterinary Drµg Residues/MOA Key Laboratory of Food Safety Evaluation, Huazhong Agricultural University, Wuhan 430070, China.
Antibiotics (Basel). 2021 Feb 3;10(2):153. doi: 10.3390/antibiotics10020153.
Cyadox has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in vitro antibacterial activities of cyadox were assayed, and the antibacterial efficacy of cyadox against facultative anaerobes was also determined under anaerobic conditions. It was shown that and (MIC = 0.25 and 1 μg/mL) from pigs, and from poultry, , spp., and from fish were highly susceptible to cyadox (MIC= 1 and 8 μg/mL). However, has no killing effect for drug tolerance. Under in vitro anaerobic conditions, the antibacterial activity of cyadox against most facultative anaerobes was considerably enhanced Under anaerobic conditions for the facultative anaerobes, susceptible bacteria were , . (including , , , , and , excluding ), , spp. (including , , and ), , , , , , and (MICs were 0.258 μg/mL, MBCs were 1-64 μg/mL). Intermediate bacteria were spp. (including and ), , and spp. (MICs mainly were 832 μg/mL, MBCs were 16~128 μg/mL). This study firstly showed that cyadox had strong antibacterial activity and had the potential to be used as a single drug in the treatment of bacterial infectious diseases.
喹乙醇在动物中具有作为抗菌剂的潜在用途。然而，其药效学特性尚未得到系统研究。在本研究中，测定了喹乙醇的体外抗菌活性，并在厌氧条件下确定了喹乙醇对兼性厌氧菌的抗菌效果。结果表明，来自猪的大肠杆菌和沙门氏菌（MIC = 0.25和1μg/mL）、来自家禽的大肠杆菌和沙门氏菌、来自鱼类的嗜水气单胞菌、温和气单胞菌、迟缓爱德华氏菌和豚鼠气单胞菌对喹乙醇高度敏感（MIC = 1和8μg/mL）。然而，喹乙醇对耐药菌没有杀灭作用。在体外厌氧条件下，喹乙醇对大多数兼性厌氧菌的抗菌活性显著增强。对于兼性厌氧菌在厌氧条件下，敏感菌有大肠杆菌、沙门氏菌（包括肠炎沙门氏菌、鼠伤寒沙门氏菌、猪霍乱沙门氏菌、鸡白痢沙门氏菌和鸭沙门氏菌，不包括甲型副伤寒沙门氏菌）、嗜水气单胞菌、温和气单胞菌、迟缓爱德华氏菌、豚鼠气单胞菌、中间气单胞菌、维氏气单胞菌、杀鲑气单胞菌（MIC为0.258μg/mL，MBC为164μg/mL）。中介菌有柠檬酸杆菌属（包括弗氏柠檬酸杆菌和异型柠檬酸杆菌）、阴沟肠杆菌和产气肠杆菌（MIC主要为832μg/mL，MBC为16128μg/mL）。本研究首次表明喹乙醇具有较强的抗菌活性，有潜力作为单一药物用于治疗细菌感染性疾病。
