Tamura Tatsuro, Ohira Masaichi, Tanaka Hiroaki, Muguruma Kazuya, Toyokawa Takahiro, Kubo Naoshi, Sakurai Katsunobu, Amano Ryosuke, Kimura Kenjiro, Shibutani Masatsune, Maeda Kiyoshi, Hirakawa Kosei
Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, Osaka, Japan
Anticancer Res. 2015 Oct;35(10):5369-76.
BACKGROUND/AIM: The cell surface receptor programmed death-1 (PD1) and its ligand (PDL1) have been detected in various cancer types. It has been reported that expression of PDL1 and PD1 in a tumor is associated with poor prognosis of the patient. In the present study, we retrospectively examined tumor expression of PDL1 and intratumoral PD1(+) cell infiltration, and assessed their relationship with patient prognosis according to the pathological stage of gastric cancer.
PDL1 and PD1 expression in primary tumors from 431 patients was evaluated using immunohistochemistry. The association between the expression of PDL1/PD1 and clinicopathological features was assessed.
High expression of PDL1 was observed in 128 (29.6%) patients. PDL1 expression was correlated with tumor infiltration of PD1(+) cells. In multivariate analysis, PDL1 expression was associated with worse overall survival. In subset analysis, PDL1 expression was significantly associated with survival in patients with stage II/III gastric cancer. In conclusion, PDL1 was an independent prognostic factor for patients with stage II/III gastric cancer. Our results suggested that patients with stage II/III gastric cancer might be appropriate for PD1/PDL1-targeted therapy.
背景/目的：在多种癌症类型中已检测到细胞表面受体程序性死亡蛋白1（PD1）及其配体（PDL1）。据报道，肿瘤中PDL1和PD1的表达与患者预后不良相关。在本研究中，我们回顾性检测了PDL1的肿瘤表达及肿瘤内PD1(+)细胞浸润情况，并根据胃癌的病理分期评估它们与患者预后的关系。
采用免疫组织化学法评估431例患者原发性肿瘤中PDL1和PD1的表达。评估PDL1/PD1表达与临床病理特征之间的关联。
128例（29.6%）患者观察到PDL1高表达。PDL1表达与PD1(+)细胞的肿瘤浸润相关。多因素分析显示，PDL1表达与总生存期较差相关。亚组分析中，PDL1表达与II/III期胃癌患者的生存显著相关。总之，PDL1是II/III期胃癌患者的独立预后因素。我们的结果提示，II/III期胃癌患者可能适合接受PD1/PDL1靶向治疗。
