Bassiouni B A, Rafei A A
Eur J Obstet Gynecol Reprod Biol. 1979 Apr;9(2):81-8. doi: 10.1016/0028-2243(79)90003-0.
Ceruloplasmin, the blue copper-protein of the blood plasma, is believed by some workers to be involved in the metabolic management of 5-hydroxytryptamine (serotonin) during pregnancy. 5-Hydroxytryptamine is abortifacient in experimental animals. By some authors, a role has been suggested for it in human abortion. The plasma concentrations of 5-hydroxytryptamine, copper and ceruloplasmin were measured in non-pregnant women, in normal early pregnancy and in cases of spontaneous abortion. Compared with normal early pregnancy, cases of inevitable abortion show lower values for both plasma copper and ceruloplasmin and higher values for plasma 5-hydroxytryptamine. The possible implications of these findings are discussed in view of the alterations in ceruloplasmin values in pregnancy and in the light of what is known of the pharmacology and metabolism of 5-hydroxytryptamine. It it believed that these alterations in plasma copper, ceruloplasmin and 5-hydroxytryptamine in cases of inevitable abortion are the effect, rather than the cause, of abortion.
血浆铜蓝蛋白是血浆中的蓝色铜蛋白，一些研究人员认为它在孕期5-羟色胺（血清素）的代谢管理中发挥作用。5-羟色胺在实验动物中具有堕胎作用。一些作者认为它在人类流产中起作用。对非孕妇、正常早孕妇女及自然流产病例的血浆5-羟色胺、铜和铜蓝蛋白浓度进行了测定。与正常早孕相比，难免流产病例的血浆铜和铜蓝蛋白值较低，而血浆5-羟色胺值较高。鉴于孕期铜蓝蛋白值的变化以及已知的5-羟色胺药理学和代谢情况，对这些发现的可能影响进行了讨论。据信，难免流产病例中血浆铜、铜蓝蛋白和5-羟色胺的这些变化是流产的结果而非原因。
