Bogdanov Vladimir Y, Versteeg Henri H
Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Department of Internal Medicine, Section of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Semin Thromb Hemost. 2015 Oct;41(7):700-7. doi: 10.1055/s-0035-1556049. Epub 2015 Sep 26.
Tissue factor (TF), the main trigger of blood coagulation, is essential for normal hemostasis. Over the past 20 years, heightened intravascular levels and activity of TF have been increasingly perceived as an entity that significantly contributes to venous as well as arterial thrombosis. Various forms of the TF protein in the circulation have been described and proposed to be thrombogenic. Aside from cell and vessel wall-associated TF, several forms of non-cell-associated TF circulate in plasma and may serve as a causative factor in thrombosis. At the present time, no firm consensus exists regarding the extent, the vascular setting(s), and/or the mechanisms by which such TF forms contribute to thrombus initiation and propagation. Here, we summarize the existing paradigms and recent, sometimes paradigm-shifting findings elucidating the structural, mechanistic, and pathophysiological characteristics of plasma-borne TF.
组织因子（TF）是血液凝固的主要触发因素，对正常止血至关重要。在过去20年中，血管内TF水平和活性的升高越来越被视为一个对静脉和动脉血栓形成有重大影响的因素。循环中TF蛋白的各种形式已被描述并被认为具有血栓形成作用。除了与细胞和血管壁相关的TF外，几种非细胞相关的TF形式在血浆中循环，可能是血栓形成的一个致病因素。目前，关于这些TF形式在何种程度、何种血管环境和/或通过何种机制促成血栓形成和传播，尚未达成明确共识。在此，我们总结了现有的模式以及最近的、有时甚至是范式转变的发现，以阐明血浆中TF的结构、机制和病理生理特征。
