急性肺栓塞患者微粒组织因子活性、凝血因子 VIII 活性与复发性静脉血栓栓塞之间的关联
Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism.
作者信息
Kooiman Judith, den Exter Paul L, Kilicsoy Inci, Cannegieter Suzanne C, Eikenboom Jeroen, Huisman Menno V, Klok Frederikus A, Versteeg Henri H
机构信息
Department of Thrombosis and Haemostasis, Leiden University Medical Center, C7-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands,
出版信息
J Thromb Thrombolysis. 2015 Oct;40(3):323-30. doi: 10.1007/s11239-015-1180-z.
UNLABELLED
Studies on the association between microparticle expressing tissue factor (MP-TF) activity, FVIII activity (
FVIII
C) and recurrent VTE yielded inconclusive results. We studied these associations in patients diagnosed with acute pulmonary embolism. Plasma levels of MP-TF and FVIII activity were measured in 277 patients with a first and 72 patients with a recurrent VTE. All patients were categorized based on the quintiles of MP-TF and FVIII activity in those with a single VTE. For both markers, odds ratios (ORs) for recurrent VTE were computed using patients in the lowest quintile as a reference group. No association was observed between MP-TF activity and recurrent VTE, with an OR of 1.4 (95 % CI 0.7-2.9) in the highest quintile of MP-TF activity. Compared with the reference group, patients in the highest quintile of
FVIII
C were at increased risk of recurrent VTE, OR 4.2 (95 % CI 1.4-12.2). MP-TF activity was not associated with recurrent VTE whereas high
FVIII
C levels were associated with a 4-fold increased risk of VTE recurrence. Future prospective studies are necessary to explore the potential of
FVIII
C as a tool for risk stratification, either by itself or in combination with other pro-thrombotic markers.
未标注
关于表达组织因子的微粒（MP-TF）活性、FVIII活性（FVIII:C）与复发性静脉血栓栓塞（VTE）之间关联的研究结果尚无定论。我们在诊断为急性肺栓塞的患者中研究了这些关联。对277例首次发生VTE的患者和72例复发性VTE患者测定了血浆MP-TF水平和FVIII活性。所有患者根据单次VTE患者中MP-TF和FVIII活性的五分位数进行分类。对于这两种标志物，以最低五分位数的患者作为参照组，计算复发性VTE的比值比（OR）。未观察到MP-TF活性与复发性VTE之间存在关联，在MP-TF活性最高五分位数中，OR为1.4（95%CI 0.7 - 2.9）。与参照组相比，FVIII:C最高五分位数的患者复发性VTE风险增加，OR为4.2（95%CI 1.4 - 12.2）。MP-TF活性与复发性VTE无关，而高FVIII:C水平与VTE复发风险增加4倍相关。未来有必要进行前瞻性研究，以探索FVIII:C作为风险分层工具的潜力，无论是单独使用还是与其他促血栓形成标志物联合使用。
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