Múnera Claudia P, Lomlomdjian Carolina, Terpiluk Verónica, Medel Nancy, Solís Patricia, Kochen Silvia
Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Gral Urquiza 609, C1221ADC CABA, Argentina; Center for Clinical and Experimental Neurosciences: Epilepsy, Cognition and Behavior, Cell Biology and Neuroscience Institute (IBCN), School of Medicine, UBA-CONICET, Paraguay 2155, 2nd Floor, C1121ABG CABA, Argentina.
Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Gral Urquiza 609, C1221ADC CABA, Argentina; Center for Clinical and Experimental Neurosciences: Epilepsy, Cognition and Behavior, Cell Biology and Neuroscience Institute (IBCN), School of Medicine, UBA-CONICET, Paraguay 2155, 2nd Floor, C1121ABG CABA, Argentina.
Epilepsy Behav. 2015 Nov;52(Pt A):57-61. doi: 10.1016/j.yebeh.2015.08.009. Epub 2015 Sep 25.
Several studies suggest that highly emotional information could facilitate long-term memory encoding and consolidation processes via an amygdala-hippocampal network. Our aim was to assess emotional perception and episodic memory for emotionally arousing material in patients with temporal lobe epilepsy (TLE) who are candidates for surgical treatment. We did this by using an audiovisual paradigm. Forty-six patients with medically resistant TLE (26 with left TLE and 20 with right TLE) and 19 healthy controls were assessed with a standard narrative test of emotional memory. The experimental task consisted of sequential picture slides with an accompanying narrative depicting a story that has an emotional central section. Subjects were asked to rate their emotional arousal reaction to each stimulus after the story was shown, while emotional memory (EM) was assessed a week later with a multiple choice questionnaire and a visual recognition task. Our results showed that ratings for emotional stimuli for the patients with TLE were significantly higher than for neutral stimuli (p=0.000). It was also observed that patients with TLE recalled significantly less information from each slide compared with controls, with a trend to lower scores on the questionnaire task for the group with LTLE, as well as poorer performance on the visual recognition task for the group with RLTE. Emotional memory was preserved in patients with RTLE despite having generally poorer memory performance compared with controls, while it was found to be impaired in patients with LTLE.
多项研究表明，高度情绪化的信息可通过杏仁核 - 海马体网络促进长期记忆的编码和巩固过程。我们的目的是评估颞叶癫痫（TLE）患者（这些患者是外科治疗的候选对象）对情绪唤起性材料的情绪感知和情景记忆。我们通过使用视听范式来进行此项研究。46例药物难治性TLE患者（26例左侧TLE和20例右侧TLE）和19名健康对照者接受了情绪记忆的标准叙述性测试。实验任务包括一系列带有叙述的图片幻灯片，叙述描绘了一个具有情感核心部分的故事。在故事展示后，要求受试者对每个刺激的情绪唤起反应进行评分，而一周后通过多项选择题问卷和视觉识别任务评估情绪记忆（EM）。我们的结果表明，TLE患者对情绪刺激的评分显著高于中性刺激（p = 0.000）。还观察到，与对照组相比，TLE患者从每张幻灯片中回忆的信息明显更少，左侧TLE组在问卷任务上有得分较低的趋势，右侧TLE组在视觉识别任务上表现较差。尽管右侧TLE患者的记忆表现总体上比对照组差，但他们的情绪记忆得以保留，而左侧TLE患者的情绪记忆则受损。
