Hossain M Z, Yamada T, Yamauchi K
Nihon Kyosei Shika Gakkai Zasshi. 1989 Oct;48(5):483-95.
This study was performed to evaluate the histological changes during remodelling of autogenous PMCB (particulate marrow and cancellous bone) and TCPC (beta-tricalcium phosphate ceramic) when transplanted into the jaw bone defects, and also to investigate the possibility of orthodontic tooth movement on them. Twenty dogs were used in this study. Following extraction of the upper 2nd and 3rd incisors, or only the 2nd incisor, maxillary alveolar bones were resected bilaterally. Autogenous PMCB obtained from the ilium and TCPC (Synthograft, Miter, Inc. U.S.A.) were grafted in each resected area. Nine dogs were sacrificed without applying the orthodontic force, whereas the rest of dogs were sacrificed after applying orthodontic force. Sectional arch wire with open coil spring was placed between the upper 1st incisors for tooth movement. Applications of orthodontic force were started anywhere from the 2nd to the 8th week following the grafting and continued for different experimental periods. Sections of maxillary bone including the grafted areas were prepared for light microscopy. It was observed that Synthograft area showed better organization than the bone graft area initially. However, later around the 8th week, both graft materials were well organized. The Synthograft was well accepted by the host tissue. The Synthograft filled area reconstructed the bony architecture more similar to the alveolar bone than the bone graft area. In addition, the radiological findings also showed orthodontic tooth movement through the PMCB and the Synthograft areas. Capability of orthodontic tooth movement at the Synthograft areas without any undue result is of significant clinical value. Thus in view of above points in conclusion it is suggested that, TCPC is a competent substitute for PMCB in filling up alveolar bone defects, even, in cases where orthodontic tooth movement is desirable.
本研究旨在评估自体PMCB（颗粒状骨髓和松质骨）和TCPC（β-磷酸三钙陶瓷）移植到颌骨缺损处重塑过程中的组织学变化，并研究在其上进行正畸牙齿移动的可能性。本研究使用了20只狗。拔除上颌第二和第三切牙或仅拔除第二切牙后，双侧切除上颌牙槽骨。将从髂骨获取的自体PMCB和TCPC（美国Miter公司的Synthograft）移植到每个切除区域。9只狗在未施加正畸力的情况下被处死，其余的狗在施加正畸力后被处死。在上颌第一切牙之间放置带有开放螺旋弹簧的分段弓丝以进行牙齿移动。正畸力在移植后的第2周至第8周的任何时间开始施加，并持续不同的实验周期。制备包括移植区域的上颌骨切片用于光学显微镜检查。观察到，最初Synthograft区域比骨移植区域显示出更好的组织状态。然而，在大约第8周时，两种移植材料都组织良好。Synthograft被宿主组织很好地接受。与骨移植区域相比，Synthograft填充区域重建的骨结构更类似于牙槽骨。此外，影像学检查结果还显示正畸牙齿移动穿过了PMCB和Synthograft区域。在Synthograft区域进行正畸牙齿移动且无任何不良结果的能力具有重要的临床价值。因此，综上所述，建议在需要正畸牙齿移动的情况下，即使在填充牙槽骨缺损方面，TCPC也是PMCB的有效替代品。
