Levin M P, Getter L, Cutright D E
J Biomed Mater Res. 1975 Mar;9(2):183-95. doi: 10.1002/jbm.820090207.
Defects were created in the tooth-supporting bone of six beagle dogs. Biodegradable tricalcium phosphate was compared to cancellous marrow as a treatment method. The findings indicated that ankylosis and resorption of the tooth can occur when using marrow. The ceramic-filled defects healed slower; but the material itself was well tolerated by the tissues, initiated new bone formation, filled in the defect, and has good potential for the treatment of advanced periodontitis.
在六只比格犬的牙齿支持骨中制造缺损。将可生物降解的磷酸三钙与松质骨髓作为治疗方法进行比较。研究结果表明，使用骨髓时可能会发生牙齿的强直和吸收。填充陶瓷的缺损愈合较慢；但该材料本身能被组织良好耐受，可启动新骨形成，填充缺损，对晚期牙周炎的治疗具有良好潜力。
