Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
Research Center Hospital, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
Semin Cancer Biol. 2015 Dec;35:45-52. doi: 10.1016/j.semcancer.2015.09.003. Epub 2015 Sep 26.
Cancer patients without metastasis are generally considered as candidates for curative localized radiation therapy. However, while the benefits of localized radiation have been demonstrated by many clinical studies, recurrences or distant metastases that develop after local treatment remain a major therapeutic challenge. Several in vitro and in vivo studies have reported that irradiation may subsequently alter tumor aggression by reducing or promoting the invasiveness of the remaining cancer cells after radiation, which appears to differ depending on the form of radiation, as well as the investigated cell lines. Cell lines recapitulate cancer heterogeneity based on the characteristics reflected in their genetic abnormalities, and thus can be used as a tool to investigate the genetic basis of cancer aggression. Importantly, molecular insights into this process would allow us to tailor drug treatments for use in combination with local radiation treatment. This review summarizes the diverse responses of cancer cell invasiveness induced by radiation, and discusses the possible molecular pathways and the genetic variations that may affect radiation-altered invasion.
无转移的癌症患者通常被认为是局部根治性放疗的候选者。然而，虽然许多临床研究已经证明了局部放疗的益处，但局部治疗后出现的复发或远处转移仍然是一个主要的治疗挑战。一些体外和体内研究报告称，照射后通过减少或促进剩余癌细胞的侵袭性，可能会随后改变肿瘤的侵袭性，这似乎因照射的形式以及所研究的细胞系而有所不同。细胞系根据其遗传异常反映的特征重现癌症异质性，因此可作为研究癌症侵袭遗传基础的工具。重要的是，对这一过程的分子见解将使我们能够调整药物治疗方案，与局部放射治疗联合使用。本综述总结了辐射诱导的癌细胞侵袭性的不同反应，并讨论了可能影响辐射改变的侵袭性的分子途径和遗传变异。
