Deng Yang, Wang Jue, Wang Ling, Du Yan
Department of Epidemiology, School of Public Health, Taishan Medical University.
Office of Clinical Epidemiology, Obstetrics and Gynecology Hospital of Fudan University.
Biosci Trends. 2017 May 23;11(2):193-201. doi: 10.5582/bst.2016.01229. Epub 2017 Feb 28.
Ovarian cancer is one of the common gynecological malignancies worldwide. It is usually diagnosed at a later stage, thus missing the best opportunity for treatment. Despite the advancement of ovarian cancer treatment, the prognosis is still poor. Androgen receptor (AR) may play a role in ovarian carcinogenesis. Previous studies regarding the association between AR CAG repeat length and ovarian cancer risk reported inconsistent results. Therefore, we conducted a meta-analysis to evaluate the association between AR CAG repeat length and ovarian cancer risk following the MOOSE guidelines. PubMed, Web of Science, EBSCO and other databases were searched up to September 15 2016. Case control studies with clear definition of CAG repeat length and detailed genotype information were included. Two authors independently reviewed and extracted data. Pooled analysis and subgroup analysis stratified by ethnicity were performed for different genetic models. Begg's funnel plot and Egger's test were performed for publication bias estimation. Overall, there was no association between the AR CAG repeat polymorphism and ovarian cancer risk. However, short CAG repeat polymorphism was associated with increased ovarian cancer risk in African Americans and Chinese under the dominant model, whereas a reverse association was observed in Caucasians and Italians under the other three models. Our study results should be interpreted with caution. Further well-designed epidemiological and functional studies are needed to elucidate the role of AR in ovarian carcinogenesis.
卵巢癌是全球常见的妇科恶性肿瘤之一。它通常在晚期才被诊断出来，从而错失了最佳治疗时机。尽管卵巢癌治疗取得了进展，但其预后仍然很差。雄激素受体（AR）可能在卵巢癌发生过程中发挥作用。先前关于AR CAG重复序列长度与卵巢癌风险之间关联的研究报告结果不一致。因此，我们按照MOOSE指南进行了一项荟萃分析，以评估AR CAG重复序列长度与卵巢癌风险之间的关联。检索了截至2016年9月15日的PubMed、Web of Science、EBSCO等数据库。纳入了明确界定CAG重复序列长度并具有详细基因型信息的病例对照研究。两位作者独立进行文献回顾和数据提取。针对不同遗传模型进行了合并分析以及按种族分层的亚组分析。采用Begg漏斗图和Egger检验进行发表偏倚估计。总体而言，AR CAG重复序列多态性与卵巢癌风险之间无关联。然而，在显性模型下，短CAG重复序列多态性与非裔美国人和中国人卵巢癌风险增加相关，而在其他三种模型下，白种人和意大利人则呈现相反的关联。我们的研究结果应谨慎解读。需要进一步设计完善的流行病学和功能研究来阐明AR在卵巢癌发生中的作用。
