The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW71AA, UK.
Trends Cell Biol. 2015 Oct;25(10):579-591. doi: 10.1016/j.tcb.2015.07.006.
Cells in developing organs undergo a series of changes in their transcriptional state until a complete repertoire of cell types is specified. These changes in cell identity, together with the control of tissue growth, determine the pattern of gene expression in the tissue. Recent studies explore the dynamics of pattern formation during development and provide new insights into the control mechanisms. Changes in morphogen signalling and transcriptional networks control the specification of cell types. This is often followed by a distinct second phase, where pattern is elaborated by tissue growth. Here, we discuss the transitions between distinct phases in pattern formation. We consider the implications of the underlying mechanisms for understanding how reproducible patterns form during development.
在器官发育过程中，细胞的转录状态会发生一系列变化，直到确定完整的细胞类型谱。这些细胞身份的变化，以及组织生长的控制，决定了组织中基因表达的模式。最近的研究探讨了发育过程中模式形成的动态，并为控制机制提供了新的见解。形态发生素信号和转录网络的变化控制着细胞类型的特化。这通常伴随着一个明显的第二阶段，即通过组织生长来详细阐述模式。在这里，我们讨论了在模式形成过程中不同阶段之间的转变。我们考虑了潜在机制对理解发育过程中如何形成可重复模式的影响。
