López de Padilla Consuelo M, Niewold Timothy B
Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Gene. 2016 Jan 15;576(1 Pt 1):14-21. doi: 10.1016/j.gene.2015.09.058. Epub 2015 Sep 26.
There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60 years ago with the concept of "viral interference", a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK-STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent.
阐明I型干扰素的生物学特性在科学和临床领域引发了越来越多的关注，这一研究始于约60年前的“病毒干扰”概念，即一种降低病毒感染细胞能力的特性。尽管我们对干扰素多种细胞和分子功能的理解已有显著进展，但仍有许多有待探索，I型干扰素仍是一个活跃且引人入胜的研究领域。在本综述中，我们涵盖了I型干扰素基因的一些一般方面，重点是干扰素-α，以及I型干扰素引发的分子机制的各个方面，以及Toll样受体通过Janus激活激酶/信号转导子和转录激活因子（JAK-STAT）途径和干扰素调节因子途径进行的信号传导。我们还将描述I型干扰素在自身免疫性和炎性疾病中的作用及其作为治疗剂的潜在用途。
