Tamminga Saskia, van Schendel Rachèl V, Rommers Wieke, Bilardo Caterina M, Pajkrt Eva, Dondorp Wybo J, van Maarle Merel, Cornel Martina C, Henneman Lidewij
Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands.
EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Prenat Diagn. 2015 Dec;35(13):1316-23. doi: 10.1002/pd.4697. Epub 2015 Oct 25.
The aim of this study was to investigate health professionals' opinions toward offering noninvasive prenatal testing (NIPT) as first-tier screening test regardless of pregnant women's risk, and toward a potential broader range of disorders.
A questionnaire completed by obstetric health professionals (n = 240) after an in-service NIPT training in the West and North of the Netherlands.
The majority (72%) of respondents favored replacing first-trimester combined test (FCT) by NIPT, although 43% preferred to maintain nuchal translucency measurement. Many respondents believed that replacing FCT by NIPT would only have advantages (57%), would lead to more pregnant women opting for prenatal testing (69%), and would simplify counseling (47%). Differences in attitudes toward counseling between health professionals were observed. When considering NIPT to screen for broader range of disorders, the majority (92%) thought that this should include disorders characterized by neonatal death, whereas 52% of the respondents favored testing for fetomaternal risk factors. Overall, 46% thought screening should be offered as a fixed list of disorders.
Most health professionals favor NIPT instead of FCT but prefer to maintain nuchal translucency measurement. If NIPT becomes available as a first-tier screening test, attention remains necessary to ensure that pregnant women make well-informed decisions in line with the aim of prenatal screening.
本研究旨在调查卫生专业人员对于无论孕妇风险如何都将无创产前检测（NIPT）作为一线筛查检测的看法，以及对于潜在更广泛疾病范围的看法。
荷兰西部和北部的产科卫生专业人员（n = 240）在参加一次在职NIPT培训后填写了一份问卷。
大多数（72%）受访者赞成用NIPT取代孕早期联合检测（FCT），尽管43%的人更倾向于保留颈部透明带测量。许多受访者认为用NIPT取代FCT只会有好处（57%），会导致更多孕妇选择产前检测（69%），并会简化咨询工作（47%）。观察到卫生专业人员在咨询态度上存在差异。在考虑用NIPT筛查更广泛的疾病范围时，大多数（92%）人认为这应包括以新生儿死亡为特征的疾病，而52%的受访者赞成检测母胎危险因素。总体而言，46%的人认为筛查应以固定的疾病清单形式提供。
大多数卫生专业人员赞成用NIPT而非FCT，但更倾向于保留颈部透明带测量。如果NIPT成为一线筛查检测，仍需注意确保孕妇根据产前筛查的目的做出明智的决定。
