Tsuru Kanji, Maruta Michito, Matsuya Shigeki, Ishikawa Kunio
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Section of Bioengineering, Department of Dental Engineering, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, 814-0193, Japan.
J Mater Sci Mater Med. 2015 Oct;26(10):244. doi: 10.1007/s10856-015-5570-8. Epub 2015 Sep 28.
Appropriate setting time is an important parameter that determines the effectiveness of apatite cement (AC) for clinical application, given the issues of crystalline inflammatory response phenomena if AC fails to set. To this end, the present study analyzes the effects of the method of apatite seed crystals addition on the setting reaction of α-tricalcium phosphate (α-TCP) based AC. Two ACs, both consisting of α-TCP and calcium deficient hydroxyapatite (cdHAp), were analyzed in this study. In one AC, cdHAp was added externally to α-TCP and this AC was abbreviated as AC(EA). In the other AC, α-TCP was partially hydrolyzed to form cdHAp on the surface of α-TCP. This AC was referred to as AC(PH). Results indicate a decrease in the setting time of both ACs with the addition of cdHAp. Among them, for the given amount of added cdHAp, AC(PH) showed relatively shorter setting time than AC(EA). Besides, the mechanical strength of the set AC(PH) was also higher than that of set AC(EA). These properties of AC(PH) were attributed to the predominant crystal growth of cdHAp in the vicinity of the α-TCP particle surface. Accordingly, it can be concluded that the partial hydrolysis of α-TCP may be a better approach to add low crystalline cdHAp onto α-TCP based AC.
合适的凝固时间是决定磷灰石骨水泥（AC）临床应用效果的一个重要参数，因为如果AC未能凝固，会出现结晶性炎症反应现象。为此，本研究分析了添加磷灰石籽晶的方法对基于α-磷酸三钙（α-TCP）的AC凝固反应的影响。本研究分析了两种均由α-TCP和缺钙羟基磷灰石（cdHAp）组成的AC。在一种AC中，cdHAp被外部添加到α-TCP中，这种AC简称为AC(EA)。在另一种AC中，α-TCP部分水解在α-TCP表面形成cdHAp。这种AC被称为AC(PH)。结果表明，添加cdHAp后两种AC的凝固时间均缩短。其中，对于给定添加量的cdHAp，AC(PH)的凝固时间比AC(EA)相对更短。此外，凝固后的AC(PH)的机械强度也高于凝固后的AC(EA)。AC(PH)的这些特性归因于cdHAp在α-TCP颗粒表面附近的优先晶体生长。因此，可以得出结论，α-TCP的部分水解可能是在基于α-TCP的AC上添加低结晶度cdHAp的更好方法。
