N-杂环卡宾催化溴代烯醛与腙的[3+3]环缩合反应：二氢哒嗪酮的高对映选择性合成
N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones.
作者信息
Zhang Chun-Lin, Wang Dong-Ling, Chen Kun-Quan, Ye Song
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Biomol Chem. 2015 Dec 14;13(46):11255-62. doi: 10.1039/c5ob01748c.
PMID:26411575
Abstract
The N-heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals and hydrazones is developed to give the corresponding chiral 4,5-dihydropyridazones in good yields with excellent enantioselectivities.
摘要
开发了氮杂环卡宾催化的溴代烯醛与腙的[3+3]环缩合反应，以良好的产率和优异的对映选择性得到相应的手性4,5-二氢哒嗪酮。
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