Yang Longfei, Zhao Yinghao, Wang Yicun, Liu Lei, Zhang Xingyi, Li Bingjin, Cui Ranji
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang street Changchun China 130041.
Curr Neuropharmacol. 2015;13(4):494-504. doi: 10.2174/1570159x1304150831150507.
Major depressive disorder is a serious mental disorder that profoundly affects an individual's quality of life. Although the aetiologies underlying this disorder remain unclear, an increasing attention has been focused on the influence imposed by psychological stress over depression. Despite limited animal models of psychological stress, significant progress has been made as to be explicated in this review to elucidate the physiopathology underlying depression and to treat depressive symptoms. Therefore, we will review classical models along with new methods that will enrich our knowledge of this disorder.
重度抑郁症是一种严重的精神障碍,深刻影响着个体的生活质量。尽管这种障碍的病因尚不清楚,但心理压力对抑郁症的影响已受到越来越多的关注。尽管心理压力的动物模型有限,但在本综述中仍有显著进展,以阐明抑郁症的生理病理学并治疗抑郁症状。因此,我们将回顾经典模型以及新方法,这些将丰富我们对这种障碍的认识。