系统性硬化症中的网状色素沉着：一例报告并文献复习
Reticulate hyperpigmentation in systemic sclerosis: a case report and review of the literature.
作者信息
Chuamanochan Mati, Haws Andrea L, Pattanaprichakul Penvadee
机构信息
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkoknoi, Bangkok, 10700, Thailand.
Department of Dermatology, University of Texas Health Science Center, 6655 Travis St., Suite 980, Houston, TX, 77030, USA.
出版信息
J Med Case Rep. 2015 Sep 28;9:219. doi: 10.1186/s13256-015-0697-2.
INTRODUCTION
Systemic sclerosis is a systemic connective tissue disease with variable cutaneous presentations. Although pigmentary disturbances have been described in systemic sclerosis, a reticulate hyperpigmentation has only been reported in one case of systemic sclerosis to date.
CASE PRESENTATION
We describe a previously healthy 51-year-old Thai woman who presented with a reticulate hyperpigmentation affecting her trunk and extremities, together with sclerodactyly and proximal sclerosis, resulting in a new diagnosis of systemic sclerosis.
CONCLUSIONS
To date, the pathogenesis of reticulate hyperpigmentation in systemic sclerosis remains unclear. Increased melanin synthesis and altered thermoregulatory mechanism are proposed to be involved in the pathogenesis of this presentation. This case represents an unusual cutaneous feature of reticulate hyperpigmentation in the setting of systemic sclerosis.
引言
系统性硬化症是一种具有多种皮肤表现的系统性结缔组织病。尽管系统性硬化症中已描述有色素紊乱，但迄今为止，仅在一例系统性硬化症中报告过网状色素沉着。
病例报告
我们描述了一名既往健康的51岁泰国女性，她出现累及躯干和四肢的网状色素沉着，同时伴有指（趾）硬皮病和近端硬化，从而确诊为系统性硬化症。
结论
迄今为止，系统性硬化症中网状色素沉着的发病机制仍不清楚。黑色素合成增加和体温调节机制改变被认为与这种表现的发病机制有关。该病例代表了系统性硬化症背景下网状色素沉着这一不寻常的皮肤特征。
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