Institut National de la Santé et de la Recherche Médicale (INSERM), Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France.
Institut National de la Santé et de la Recherche Médicale (INSERM), Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; Endocrinology Department, Haut-Lévêque Hospital, 33604 Pessac, France.
Trends Endocrinol Metab. 2015 Oct;26(10):524-537. doi: 10.1016/j.tem.2015.07.007.
The endocannabinoid system (ECS) functions to adjust behavior and metabolism according to environmental changes in food availability. Its actions range from the regulation of sensory responses to the development of preference for the consumption of calorically-rich food and control of its metabolic handling. ECS activity is beneficial when access to food is scarce or unpredictable. However, when food is plentiful, the ECS favors obesity and metabolic disease. We review recent advances in understanding the roles of the ECS in energy balance, and discuss newly identified mechanisms of action that, after the withdrawal of first generation cannabinoid type 1 (CB1) receptor antagonists for the treatment of obesity, have made the ECS once again an attractive target for therapy.
内源性大麻素系统（ECS）的功能是根据食物供应的环境变化来调节行为和新陈代谢。它的作用范围从调节感官反应到发展对高热量食物的消费偏好，以及控制其代谢处理。当食物稀缺或不可预测时，ECS 的活动是有益的。然而，当食物充足时，ECS 有利于肥胖和代谢疾病。我们回顾了最近在理解 ECS 在能量平衡中的作用方面的进展，并讨论了新发现的作用机制，这些机制在第一代大麻素 1 型（CB1）受体拮抗剂被撤出用于治疗肥胖症后，使 ECS 再次成为治疗的一个有吸引力的靶点。
