• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于评估血脑屏障特性的血浆和脑脊液中地氟醚、丙泊酚和芬太尼的膜进样质谱分析

Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties.

作者信息

Cherebillo Vyacheslav Yu, Elizarov Andrei Yu, Polegaev Andrei V

机构信息

Kirov Medical Academy, St. Petersburg 194 044, Russia.

Ioffe Physical-Technical Institute, St. Petersburg 194 026, Russia.

出版信息

Exp Neurobiol. 2015 Sep;24(3):206-10. doi: 10.5607/en.2015.24.3.206. Epub 2015 Sep 22.

DOI:10.5607/en.2015.24.3.206
PMID:26412969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4580747/
Abstract

A possibility to use the Membrane-Introduction Mass Spectrometry (MIMS) with membrane separator interface has evolved into a powerful method for measurement of anaesthetic agents absolute concentration in blood plasma and cerebrospinal fluid for the study of blood-brain barrier (BBB) properties. Recent advanced a new membrane material was used for drug concentration measurement in biologic fluids. A hydrophobic membrane was used in the interface to separate anaesthetic agents from biological fluids: inhalational anaesthetic desflurane,hypnotic propofol, analgesic fentanyl. The selective detection of volatile anesthetic agents in blood does not require long-term sample processing before injecting the sample into mass-spectrometer interface, in contrast to chromatographic methods. Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced inhalational (desflurane, fentanyl) anaesthesia and total intravenous (propofol, fentanyl) anaesthesia.

摘要

使用带有膜分离器接口的膜引入质谱法（MIMS）已发展成为一种强大的方法，用于测量血浆和脑脊液中麻醉剂的绝对浓度，以研究血脑屏障（BBB）的特性。最近的进展是采用了一种新型膜材料用于生物流体中药物浓度的测量。在接口中使用疏水膜将麻醉剂与生物流体分离：吸入性麻醉剂地氟烷、催眠药丙泊酚、镇痛药芬太尼。与色谱法相比，血液中挥发性麻醉剂的选择性检测在将样品注入质谱仪接口之前不需要长时间的样品处理。描述了用于测量生物流体（血浆和脑脊液）中麻醉剂浓度的质谱接口。在平衡吸入（地氟烷、芬太尼）麻醉和全静脉（丙泊酚、芬太尼）麻醉期间进行生物流体的采样。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/fb1591699fdd/en-24-206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/aea4099a72f3/en-24-206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/009f78b923e3/en-24-206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/4a218825cc3c/en-24-206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/1e979f34b95e/en-24-206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/fb1591699fdd/en-24-206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/aea4099a72f3/en-24-206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/009f78b923e3/en-24-206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/4a218825cc3c/en-24-206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/1e979f34b95e/en-24-206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad98/4580747/fb1591699fdd/en-24-206-g005.jpg

相似文献

1
Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties.用于评估血脑屏障特性的血浆和脑脊液中地氟醚、丙泊酚和芬太尼的膜进样质谱分析
Exp Neurobiol. 2015 Sep;24(3):206-10. doi: 10.5607/en.2015.24.3.206. Epub 2015 Sep 22.
2
A comparison between inhalational (Desflurane) and total intravenous anaesthesia (Propofol and dexmedetomidine) in improving postoperative recovery for morbidly obese patients undergoing laparoscopic sleeve gastrectomy: A double-blinded randomised controlled trial.吸入麻醉（地氟醚）与全静脉麻醉（丙泊酚和右美托咪定）在改善病态肥胖患者行腹腔镜袖状胃切除术术后恢复的比较：一项双盲随机对照试验。
J Clin Anesth. 2018 Mar;45:6-11. doi: 10.1016/j.jclinane.2017.12.001. Epub 2017 Dec 8.
3
Early recovery, cognitive function and costs of a desflurane inhalational vs. a total intravenous anaesthesia regimen in long-term surgery.长期手术中地氟烷吸入麻醉与全静脉麻醉方案的早期恢复、认知功能及成本
Acta Anaesthesiol Scand. 2006 Jan;50(1):14-8. doi: 10.1111/j.1399-6576.2006.00905.x.
4
Insignificant effect of desflurane-fentanyl-thiopental on hepatocellular integrity--a comparison with total intravenous anaesthesia using propofol-remifentanil.地氟醚-芬太尼-硫喷妥钠对肝细胞完整性影响不大——与丙泊酚-瑞芬太尼全静脉麻醉的比较
Eur J Anaesthesiol. 2005 Mar;22(3):209-14. doi: 10.1017/s0265021505000360.
5
[Desflurane and isoflurane. A comparison of recovery and circulatory parameters in surgical interventions].[地氟烷和异氟烷。外科手术中恢复情况及循环参数的比较]
Anaesthesist. 1996 Jan;45(1):37-46. doi: 10.1007/s001010050238.
6
New generation pulse oximetry in the assessment of peripheral perfusion during general anaesthesia - a comparison between propofol and desflurane.新一代脉搏血氧饱和度仪在全身麻醉期间外周灌注评估中的应用——丙泊酚与地氟醚的比较
Anaesthesiol Intensive Ther. 2013 Jul-Sep;45(3):138-44. doi: 10.5603/AIT.2013.0029.
7
[Remifentanil in gynecologic laparoscopy. A comparison of consciousness and circulatory effects of a combination with desflurane and propofol].[瑞芬太尼在妇科腹腔镜手术中的应用。与地氟烷和丙泊酚联合使用时对意识和循环系统影响的比较]
Anasthesiol Intensivmed Notfallmed Schmerzther. 1998 Sep;33(9):552-6. doi: 10.1055/s-2007-994810.
8
Comparison of propofol and desflurane for postanaesthetic morbidity in patients undergoing surgery for aneurysmal SAH: a randomized clinical trial.丙泊酚与地氟醚用于动脉瘤性蛛网膜下腔出血手术患者麻醉后并发症的比较：一项随机临床试验。
J Anesth. 2018 Apr;32(2):250-258. doi: 10.1007/s00540-018-2474-z. Epub 2018 Mar 1.
9
[Adverse effects and recovery after total intravenous anesthesia in children].[小儿全静脉麻醉后的不良反应与恢复情况]
Med Pregl. 1998 Jan-Feb;51(1-2):68-72.
10
Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy.在接受经蝶窦垂体切除术的正常碳酸血症患者中，地氟烷和异氟烷会增加腰段脑脊液压力。
Anesthesiology. 1996 Nov;85(5):999-1004. doi: 10.1097/00000542-199611000-00006.

本文引用的文献

1
Investigation of cross-linked and additive containing polymer materials for membranes with improved performance in pervaporation and gas separation.对含交联剂和添加剂的聚合物材料进行研究，以制备在渗透汽化和气体分离方面具有改进性能的膜。
Membranes (Basel). 2012 Oct 22;2(4):727-63. doi: 10.3390/membranes2040727.
2
Sevoflurane concentrations in blood, brain, and lung after sevoflurane-induced death.七氟醚诱导死亡后血液、脑和肺中的七氟醚浓度。
J Forensic Sci. 2007 Nov;52(6):1408-10. doi: 10.1111/j.1556-4029.2007.00556.x. Epub 2007 Oct 17.
3
Membrane introduction mass spectrometry: trends and applications.
膜进样质谱法：趋势与应用
Mass Spectrom Rev. 2000 Jan-Feb;19(1):1-37. doi: 10.1002/(SICI)1098-2787(2000)19:1<1::AID-MAS1>3.0.CO;2-Y.
4
Active transport of fentanyl by the blood-brain barrier.芬太尼通过血脑屏障的主动转运。
J Pharmacol Exp Ther. 1999 May;289(2):1084-9.
5
Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues.I-653、七氟烷、异氟烷和氟烷在人体组织中的溶解度。
Anesth Analg. 1989 Sep;69(3):370-3.
6
Differentiation of brain endothelial cells in cell culture.细胞培养中脑内皮细胞的分化
Ann N Y Acad Sci. 1991;633:420-5. doi: 10.1111/j.1749-6632.1991.tb15631.x.