Yasuda N, Targ A G, Eger E I
Department of Anesthesia, University of California, San Francisco 94143-0464.
Anesth Analg. 1989 Sep;69(3):370-3.
Tissue/blood partition coefficients of anesthetics are important indicators of the rate of tissue wash-in and wash-out, and wash-in and wash-out are determinants of the rates of induction of and recovery from anesthesia. In the present study of human tissues, we found that the tissue/blood partition coefficients (for brain, heart, liver, kidney, muscle, and fat) for the new anesthetic I-653 were smaller than those for isoflurane, sevoflurane, and halothane (anesthetics listed in order of increasing tissue/blood partition coefficients). For example, the respective brain/blood partition coefficients were 1.29 +/- 0.05 (mean +/- SD); 1.57 +/- 0.10; 1.70 +/- 0.09; and 1.94 +/- 0.17. This indicates that induction of and recovery from anesthesia with I-653 should be more rapid than with the other agents. The finding of a lower tissue/blood partition coefficient for I-653 parallels the previous finding of a lower blood/gas partition coefficient.
麻醉剂的组织/血液分配系数是组织吸入和排出速率的重要指标，而吸入和排出是麻醉诱导和恢复速率的决定因素。在目前对人体组织的研究中，我们发现新型麻醉剂I - 653的组织/血液分配系数（针对脑、心脏、肝脏、肾脏、肌肉和脂肪）低于异氟烷、七氟烷和氟烷（按组织/血液分配系数递增顺序列出的麻醉剂）。例如，各自的脑/血分配系数分别为1.29±0.05（平均值±标准差）；1.57±0.10；1.70±0.09；以及1.94±0.17。这表明使用I - 653进行麻醉诱导和恢复应该比使用其他药物更快。I - 653的组织/血液分配系数较低这一发现与之前较低的血/气分配系数的发现一致。
