睾丸和附睾毒性的形态学表现。
Morphologic manifestations of testicular and epididymal toxicity.
作者信息
Vidal Justin D, Whitney Katharine M
机构信息
GSK ; King of Prussia, PA USA.
AbbVie; GPRD Preclinical Safety ; Chicago, IL USA.
出版信息
Spermatogenesis. 2014 Dec 31;4(2):e979099. doi: 10.4161/21565562.2014.979099. eCollection 2014 May-Aug.
Abstract
Histopathologic examination of the testis is the most sensitive means to detect effects on spermatogenesis; however, the complexity of testicular histology, interrelatedness of cell types within the testis, and long duration of spermatogenesis can make assessment of a testicular toxicant challenging. A thorough understanding of the histology and morphologic manifestations of response to injury is critical to successfully identify a testicular effect and to begin to understand the underlying mechanism of action. The basic patterns of response to xenobiotic-induced injury to the testis and epididymis are detailed and discussed.
摘要
睾丸的组织病理学检查是检测对精子发生影响的最敏感方法；然而，睾丸组织学的复杂性、睾丸内细胞类型的相互关联性以及精子发生的长时间过程，可能使评估睾丸毒性物质具有挑战性。全面了解损伤反应的组织学和形态学表现对于成功识别睾丸效应并开始理解其潜在作用机制至关重要。本文详细阐述并讨论了外源化学物诱导的睾丸和附睾损伤的基本反应模式。
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