Li Xun, Zang Yu-Feng, Zhang Han
Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou 311121, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
Biomed Res Int. 2015;2015:824710. doi: 10.1155/2015/824710. Epub 2015 Aug 27.
We applied a "temporal decomposition" method, which decomposed a single brain functional network into several "modes"; each of them dominated a short temporal period, on a continuous, "state-" related, "finger-force feedback" functional magnetic resonance imaging experiment. With the hypothesis that attention and internal/external information processing interaction could be manipulated by different (real and sham) feedback conditions, we investigated functional network dynamics of the "default mode," "executive control," and sensorimotor networks. They were decomposed into several modes. During real feedback, the occurrence of "default mode-executive control competition-related" mode was higher than that during sham feedback (P = 0.0003); the "default mode-visual facilitation-related" mode more frequently appeared during sham than real feedback (P = 0.0004). However, the dynamics of the sensorimotor network did not change significantly between two conditions (P > 0.05). Our results indicated that the visual-guided motor feedback involves higher cognitive functional networks rather than primary motor network. The dynamics monitoring of inner and outside environment and multisensory integration could be the mechanisms. This study is an extension of our previous region-specific and static-styled study of our brain functional architecture.
我们应用了一种“时间分解”方法，该方法将单个脑功能网络分解为几种“模式”；在一项连续的、与“状态”相关的“手指力反馈”功能磁共振成像实验中，每种模式在较短的时间段内占主导地位。基于注意力与内部/外部信息处理交互作用可被不同（真实和假）反馈条件所操控的假设，我们研究了“默认模式”“执行控制”和感觉运动网络的功能网络动力学。它们被分解为几种模式。在真实反馈期间，“默认模式 - 执行控制竞争相关”模式的出现频率高于假反馈期间（P = 0.0003）；“默认模式 - 视觉促进相关”模式在假反馈期间比真实反馈期间更频繁出现（P = 0.0004）。然而，感觉运动网络的动力学在两种条件之间没有显著变化（P > 0.05）。我们的结果表明，视觉引导的运动反馈涉及更高层次的认知功能网络而非初级运动网络。对内部和外部环境的动态监测以及多感官整合可能是其机制。本研究是我们之前对脑功能结构进行的区域特异性和静态样式研究的扩展。
