Smith Ellen M, Tangpricha Vin
aNutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University bDivision of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta cAtlanta VA Medical Center, Decatur, Georgia, USA.
Curr Opin Endocrinol Diabetes Obes. 2015 Dec;22(6):432-8. doi: 10.1097/MED.0000000000000199.
The current review highlights recent findings in the emerging association between vitamin D and anemia through discussion of mechanistic studies, epidemiologic studies, and clinical trials.
Vitamin D has previously been found to be associated with anemia in various healthy and diseased populations. Recent studies indicate that the association may differ between race and ethnic groups and is likely specific to anemia of inflammation. The mechanism underlying this association involves the reduction of proinflammatory cytokines by vitamin D and the direct suppression of hepcidin mRNA transcription. There is also evidence that vitamin D may be protective against anemia by supporting erythropoiesis. Other calciotropic hormones including fibroblast growth factor 23, and parathyroid hormone have also been found to be associated with iron homeostasis and erythropoiesis.
Recent advances in our understanding of the association between vitamin D and anemia suggest that maintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation. Early clinical trials have been promising, but further research is needed to define the efficacy of vitamin D as a future approach for the treatment of anemia.
本综述通过讨论机制研究、流行病学研究和临床试验，重点介绍了维生素D与贫血之间新出现的关联的最新研究结果。
此前已发现维生素D在各种健康和患病群体中均与贫血有关。最近的研究表明，这种关联在不同种族和族裔群体中可能有所不同，并且可能特定于炎症性贫血。这种关联的潜在机制包括维生素D减少促炎细胞因子以及直接抑制铁调素mRNA转录。也有证据表明维生素D可能通过支持红细胞生成来预防贫血。其他钙调节激素，包括成纤维细胞生长因子23和甲状旁腺激素，也被发现与铁稳态和红细胞生成有关。
我们对维生素D与贫血之间关联的理解方面的最新进展表明，维持充足的维生素D水平对于预防贫血可能很重要，尤其是在以炎症为特征的疾病中。早期临床试验前景良好，但需要进一步研究以确定维生素D作为未来贫血治疗方法的疗效。
